Blueberry Extracts as a Novel Approach to Prevent Ozone-Induced Cutaneous Inflammasome Activation
Joint Authors
Grace, Mary H.
Lila, Mary Ann
Pambianchi, Erika
Ferrara, Francesca
Pecorelli, Alessandra
Woodby, Brittany
Therrien, Jean-Philippe
Giuseppe, Valacchi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The World Health Organization estimates that 7 million people die every year due to pollution exposure.
Among the different pollutants to which living organism are exposed, ozone (O3) represents one of the most toxic, because its location which is the skin is one of the direct tissues exposed to the outdoor environment.
Chronic exposure to outdoor stressors can alter cutaneous redox state resulting in the activation of inflammatory pathways.
Recently, a new player in the inflammation mechanism was discovered: the multiprotein complex NLRP1 inflammasome, which has been shown to be also expressed in the skin.
The topical application of natural compounds has been studied for the last 40 years as a possible approach to prevent and eventually cure skin conditions.
Recently, the possibility to use blueberry (BB) extract to prevent pollution-induced skin toxicity has been of great interest in the cosmeceutical industry.
In the present study, we analyzed the cutaneous protective effect of BB extract in several skin models (2D, 3D, and human skin explants).
Specifically, we observed that in the different skin models used, BB extracts were able to enhance keratinocyte wound closure and normalize proliferation and migration responses previously altered by O3.
In addition, pretreatment with BB extracts was able to prevent ozone-induced ROS production and inflammasome activation measured as NRLP1-ASC scaffold formation and also prevent the transcripts of key inflammasome players such as CASP1 and IL-18, suggesting that this approach as a possible new technology to prevent cutaneous pollution damage.
Our data support the hypothesis that BB extracts can effectively reduce skin inflammation and be a possible new technology against cutaneous pollution-induced damage.
American Psychological Association (APA)
Pambianchi, Erika& Ferrara, Francesca& Pecorelli, Alessandra& Woodby, Brittany& Grace, Mary H.& Therrien, Jean-Philippe…[et al.]. 2020. Blueberry Extracts as a Novel Approach to Prevent Ozone-Induced Cutaneous Inflammasome Activation. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1206090
Modern Language Association (MLA)
Pambianchi, Erika…[et al.]. Blueberry Extracts as a Novel Approach to Prevent Ozone-Induced Cutaneous Inflammasome Activation. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1206090
American Medical Association (AMA)
Pambianchi, Erika& Ferrara, Francesca& Pecorelli, Alessandra& Woodby, Brittany& Grace, Mary H.& Therrien, Jean-Philippe…[et al.]. Blueberry Extracts as a Novel Approach to Prevent Ozone-Induced Cutaneous Inflammasome Activation. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1206090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206090