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Antioxidant Supplementation in Renal Replacement Therapy Patients: Is There Evidence?
Joint Authors
Roumeliotis, Stefanos
Dounousi, E.
Liakopoulos, Vassilios
Eleftheriadis, Theodoros
Bozikas, Andreas
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-15
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
The disruption of balance between production of reactive oxygen species and antioxidant systems in favor of the oxidants is termed oxidative stress (OS).
To counteract the damaging effects of prooxidant free radicals, all aerobic organisms have antioxidant defense mechanisms that are aimed at neutralizing the circulating oxidants and repair the resulting injuries.
Antioxidants are either endogenous (the natural defense mechanisms produced by the human body) or exogenous, found in supplements and foods.
OS is present at the early stages of chronic kidney disease, augments progressively with renal function deterioration, and is further exacerbated by renal replacement therapy.
End-stage renal disease patients, on hemodialysis (HD) or peritoneal dialysis (PD), suffer from accelerated OS, which has been associated with increased risk for mortality and cardiovascular disease.
During HD sessions, the bioincompatibility of dialyzers and dialysate trigger activation of white blood cells and formation of free radicals, while a significant loss of antioxidants is also present.
In PD, the bioincompatibility of solutions, including high osmolality, elevated lactate levels, low pH, and accumulation of advanced glycation end-products trigger formation of prooxidants, while there is significant loss of vitamins in the ultrafiltrate.
A number of exogenous antioxidants have been suggested to ameliorate OS in dialysis patients.
Vitamins B, C, D, and E, coenzyme Q10, L-carnitine, a-lipoic acid, curcumin, green tea, flavonoids, polyphenols, omega-3 polyunsaturated fatty acids, statins, trace elements, and N-acetylcysteine have been studied as exogenous antioxidant supplements in both PD and HD patients.
American Psychological Association (APA)
Liakopoulos, Vassilios& Roumeliotis, Stefanos& Bozikas, Andreas& Eleftheriadis, Theodoros& Dounousi, E.. 2019. Antioxidant Supplementation in Renal Replacement Therapy Patients: Is There Evidence?. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-23.
https://search.emarefa.net/detail/BIM-1206112
Modern Language Association (MLA)
Liakopoulos, Vassilios…[et al.]. Antioxidant Supplementation in Renal Replacement Therapy Patients: Is There Evidence?. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-23.
https://search.emarefa.net/detail/BIM-1206112
American Medical Association (AMA)
Liakopoulos, Vassilios& Roumeliotis, Stefanos& Bozikas, Andreas& Eleftheriadis, Theodoros& Dounousi, E.. Antioxidant Supplementation in Renal Replacement Therapy Patients: Is There Evidence?. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-23.
https://search.emarefa.net/detail/BIM-1206112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206112