Revisiting Tumors and the Cardiovascular System: Mechanistic Intersections and Divergences in Ferroptosis
Joint Authors
Tian, Jinwei
Zhang, Maomao
Wang, Yani
Peng, Xiang
Jia, Ying
Yu, Bo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Ferroptosis was recently identified as an iron-dependent regulatory necrosis process mediated by polyunsaturated fatty acid (PUFA) peroxidation.
The pivotal events related to oxidative stress in ferroptosis include direct or indirect glutathione peroxidase 4 (GPX4) inhibition, ferrous iron overload, and lipid peroxidation.
The links between ferroptosis and multiple pathological processes including tumor and cardiovascular system disease have become increasingly apparent, and the mechanisms and compounds involved in ferroptosis, such as reduction of coenzyme Q10 (ubiquinone/CoQ10), are gradually emerging.
Current reports have revealed crossroads between ferroptosis and other multiple responses.
This overview of the current research illuminates the mechanisms involving ferroptosis-related compounds and emphasizes the crosstalk between ferroptosis and other responses, including mitochondrial damage, endoplasmic reticulum stress (ER stress), autophagy, and the release of damage-associated molecular patterns (DAMPs), to reveal the intersections of regulatory mechanisms.
This review also outlines the discovery, characterization, and pathological relevance of ferroptosis and notes controversial elements in ferroptosis-related mechanisms, such as nuclear factor E2-related factor 2 (Nrf2), sequestosome 1 (p62/SQSTM1), and heat shock protein family A member 5 (HSPA5).
We hope our inferences will supply a partial reference for disorder prevention and treatment.
American Psychological Association (APA)
Wang, Yani& Peng, Xiang& Zhang, Maomao& Jia, Ying& Yu, Bo& Tian, Jinwei. 2020. Revisiting Tumors and the Cardiovascular System: Mechanistic Intersections and Divergences in Ferroptosis. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1206126
Modern Language Association (MLA)
Wang, Yani…[et al.]. Revisiting Tumors and the Cardiovascular System: Mechanistic Intersections and Divergences in Ferroptosis. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1206126
American Medical Association (AMA)
Wang, Yani& Peng, Xiang& Zhang, Maomao& Jia, Ying& Yu, Bo& Tian, Jinwei. Revisiting Tumors and the Cardiovascular System: Mechanistic Intersections and Divergences in Ferroptosis. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1206126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206126