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Effect of Interaction between Early Menarche and Genetic Polymorphisms on Triglyceride
Joint Authors
Park, Taesung
Lee, Ho-Sun
Leem, Sangseob
Oh, Bermseok
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Early menarche has been associated with increased risk of metabolic syndrome.
Therefore, investigating the association of each component of metabolic syndrome with age at menarche, and interactions between them, might lead to a better understanding of metabolic syndrome pathogenesis.
In this study, we evaluated age at menarche for risk of metabolic syndrome and associations with its components.
As a result, the risk of MetS incidence was significantly increased only at ≤12 years of age at menarche (OR = 1.91, P<0.05).
Women with early menarche (≤12 years) had significantly higher levels of triglycerides (β coefficient = 37.83, P=0.02).
In addition, hypertriglyceridemia was significantly increased at early menarche with 1.99 (95% CI: 1.16–3.41, P<0.01).
With GWAS-based pathway analysis, we found the type 2 diabetes mellitus, stress-activated protein kinase signaling, and Jun amino-terminal kinase cascade pathways (all nominal P<0.001, all FDR < 0.05) to be significantly involved with early menarche on triglyceride levels.
These findings may help us understand the role of early menarche on triglyceride and interaction between gene and early menarche on triglyceride for the development of metabolic syndrome.
American Psychological Association (APA)
Lee, Ho-Sun& Leem, Sangseob& Oh, Bermseok& Park, Taesung. 2019. Effect of Interaction between Early Menarche and Genetic Polymorphisms on Triglyceride. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1206142
Modern Language Association (MLA)
Lee, Ho-Sun…[et al.]. Effect of Interaction between Early Menarche and Genetic Polymorphisms on Triglyceride. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1206142
American Medical Association (AMA)
Lee, Ho-Sun& Leem, Sangseob& Oh, Bermseok& Park, Taesung. Effect of Interaction between Early Menarche and Genetic Polymorphisms on Triglyceride. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1206142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206142