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New Insights into the Process of Placentation and the Role of Oxidative Uterine Microenvironment
Joint Authors
Almeida, Henrique
Mendes, S.
Silva, E.
Timóteo-Ferreira, Filipa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-25
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
For a successful pregnancy to occur, a predecidualized receptive endometrium must be invaded by placental differentiated cells (extravillous trophoblast cells (EVTs)) and, at the same time, continue decidualization.
EVT invasion is aimed at anchoring the placenta to the maternal uterus and ensuring local blood supply increase necessary to provide normal placental and foetal development.
The first is achieved by migrating through the maternal endometrium and deeper into the myometrium, while the second by transforming uterine spiral arteries into large vessels.
This process is a tightly regulated battle comprising interests of both the mother and the foetus.
Invading EVTs are required to perform a scope of functions: move, adhere, proliferate, differentiate, interact, and digest the extracellular matrix (ECM); tolerate hypoxia; transform the maternal spiral arteries; and die by apoptosis.
All these functions are modulated by their surrounding microenvironment: oxygen, soluble factors (e.g., cytokines, growth factors, and hormones), ECM proteins, and reactive oxygen species.
A deeper comprehension of oxidative uterine microenvironment contribution to trophoblast function will be addressed in this review.
American Psychological Association (APA)
Mendes, S.& Timóteo-Ferreira, Filipa& Almeida, Henrique& Silva, E.. 2019. New Insights into the Process of Placentation and the Role of Oxidative Uterine Microenvironment. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1206174
Modern Language Association (MLA)
Mendes, S.…[et al.]. New Insights into the Process of Placentation and the Role of Oxidative Uterine Microenvironment. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-18.
https://search.emarefa.net/detail/BIM-1206174
American Medical Association (AMA)
Mendes, S.& Timóteo-Ferreira, Filipa& Almeida, Henrique& Silva, E.. New Insights into the Process of Placentation and the Role of Oxidative Uterine Microenvironment. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1206174
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206174