Vagus Nerve Stimulation Attenuates Acute Skeletal Muscle Injury Induced by Ischemia-Reperfusion in Rats
Joint Authors
Yang, Sheng-Li
Wang, Menglong
Meng, Guannan
Wang, Meng
Jiang, Hong
Wang, Zhenya
Deng, Jielin
Zhang, Yifeng
Li, Hewei
Zhang, Qianqian
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Vagus nerve stimulation (VNS) has been shown to attenuate ischemia-reperfusion (I/R) injury in multiple organs.
The present study aimed at investigating whether VNS could exert protective effects against I/R injury in the skeletal muscle.
Male Sprague-Dawley rats were randomly divided into 3 groups: the control, I/R, and I/R+VNS groups.
The skeletal muscle I/R (SMI/R) model was induced by occlusion of the left femoral artery for 2.5 hours followed by reperfusion for 2 hours.
The vagal nerve trunk was separated, and VNS was performed during the whole I/R process.
The intensity of VNS was optimized in each rat to obtain a 10% reduction in the heart rate relative to the value before stimulation.
After the experiment, the blood sample and left gastrocnemius muscle tissues were collected for histological examination, biochemical analysis, and molecular biological detection.
During the I/R process, VNS significantly reduced cellular apoptosis, necrosis, and inflammatory cell infiltration compared to sham VNS.
The VNS treatment also decreased the inflammatory response, alleviated oxidative stress, and improved vascular endothelial function (p<0.05 for each).
In contrast, the I/R group showed an opposite effect compared to the control group.
The present study indicated that VNS could protect against SMI/R injury by suppressing excessive inflammation, alleviating oxidative stress, and preserving vascular endothelial function.
American Psychological Association (APA)
Zhang, Yifeng& Li, Hewei& Wang, Menglong& Meng, Guannan& Wang, Zhenya& Deng, Jielin…[et al.]. 2019. Vagus Nerve Stimulation Attenuates Acute Skeletal Muscle Injury Induced by Ischemia-Reperfusion in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1206201
Modern Language Association (MLA)
Zhang, Yifeng…[et al.]. Vagus Nerve Stimulation Attenuates Acute Skeletal Muscle Injury Induced by Ischemia-Reperfusion in Rats. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1206201
American Medical Association (AMA)
Zhang, Yifeng& Li, Hewei& Wang, Menglong& Meng, Guannan& Wang, Zhenya& Deng, Jielin…[et al.]. Vagus Nerve Stimulation Attenuates Acute Skeletal Muscle Injury Induced by Ischemia-Reperfusion in Rats. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1206201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206201