Dihydrotanshinone-Induced NOX5 Activation Inhibits Breast Cancer Stem Cell through the ROSStat3 Signaling Pathway
Joint Authors
Jeong, Dong Kee
Kim, Su-Lim
Choi, Hack Sun
Kim, Ji-Hyang
Kim, Ki-Seok
Lee, Dong-Sun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-24
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Cancer stem cells (CSCs) are known to mediate metastasis and recurrence and are therefore a promising therapeutic target.
In this study, we found that dihydrotanshinone (DHTS) inhibits CSC formation.
DHTS inhibited mammosphere formation in a dose-dependent manner and showed significant tumor growth inhibition in a xenograft model.
This compound reduced the CD44high/CD24low- and aldehyde dehydrogenase- (ALDH-) expressing cell population and the self-renewal-related genes Nanog, SOX2, OCT4, C-Myc, and CD44.
DHTS induced NOX5 activation by increasing calcium, and NOX5 activation induced reactive oxygen species (ROS) production.
ROS production reduced the nuclear phosphorylation levels of Stat3 and secreted IL-6 levels in the mammospheres.
DHTS deregulated the dynamic equilibrium from non-stem cancer cells to CSCs by dephosphorylating Stat3 and decreasing IL-6 secretion and inhibiting CSC formation.
These novel findings showed that DHTS-induced ROS deregulated the Stat3/IL-6 pathway and induced CSC death.
NOX5 activation by DHTS inhibits CSC formation through ROS/Stat3/IL-6 signaling, and DHTS may be a promising potential therapeutic agent against breast CSCs.
American Psychological Association (APA)
Kim, Su-Lim& Choi, Hack Sun& Kim, Ji-Hyang& Jeong, Dong Kee& Kim, Ki-Seok& Lee, Dong-Sun. 2019. Dihydrotanshinone-Induced NOX5 Activation Inhibits Breast Cancer Stem Cell through the ROSStat3 Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1206320
Modern Language Association (MLA)
Kim, Su-Lim…[et al.]. Dihydrotanshinone-Induced NOX5 Activation Inhibits Breast Cancer Stem Cell through the ROSStat3 Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1206320
American Medical Association (AMA)
Kim, Su-Lim& Choi, Hack Sun& Kim, Ji-Hyang& Jeong, Dong Kee& Kim, Ki-Seok& Lee, Dong-Sun. Dihydrotanshinone-Induced NOX5 Activation Inhibits Breast Cancer Stem Cell through the ROSStat3 Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1206320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206320