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Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development
Joint Authors
Cuadrado, Antonio
Manda, Gina
Robledinos-Antón, Natalia
Fernández-Ginés, Raquel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-14
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
The transcription factor NRF2 (nuclear factor erythroid 2-related factor 2) triggers the first line of homeostatic responses against a plethora of environmental or endogenous deviations in redox metabolism, proteostasis, inflammation, etc.
Therefore, pharmacological activation of NRF2 is a promising therapeutic approach for several chronic diseases that are underlined by oxidative stress and inflammation, such as neurodegenerative, cardiovascular, and metabolic diseases.
A particular case is cancer, where NRF2 confers a survival advantage to constituted tumors, and therefore, NRF2 inhibition is desired.
This review describes the electrophilic and nonelectrophilic NRF2 activators with clinical projection in various chronic diseases.
We also analyze the status of NRF2 inhibitors, which at this time provide proof of concept for blocking NRF2 activity in cancer therapy.
American Psychological Association (APA)
Robledinos-Antón, Natalia& Fernández-Ginés, Raquel& Manda, Gina& Cuadrado, Antonio. 2019. Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-20.
https://search.emarefa.net/detail/BIM-1206363
Modern Language Association (MLA)
Robledinos-Antón, Natalia…[et al.]. Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-20.
https://search.emarefa.net/detail/BIM-1206363
American Medical Association (AMA)
Robledinos-Antón, Natalia& Fernández-Ginés, Raquel& Manda, Gina& Cuadrado, Antonio. Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-20.
https://search.emarefa.net/detail/BIM-1206363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206363