Cognition Deficits in Parkinson’s Disease: Mechanisms and Treatment
Joint Authors
Lv, Longqin
Mao, Shanping
Dong, Huimin
Fang, Congcong
Liu, Baohui
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder mainly in middle-elderly population, which represents diverse nonmotor symptoms (NMS) besides such well-documented motor symptoms as bradykinesia, resting tremor, rigidity, and postural instability.
With the advancement of aging trend worldwide, the global prevalence of PD is mounting up year after year.
Nowadays, accumulating lines of studies have given a comprehensive and thorough coverage of motor symptoms in PD.
Yet much less attention as compared has been paid to the nonmotor symptoms of PD, such as cognition deficits.
Of note, a patient with PD who suffers from cognitive impairment may harbour a statistically significantly higher risk of progressing toward dementia, which negatively affects their life expectancy and daily functioning and overall lowers the global quality of life.
Furthermore, it is a widely held view that cognitive dysfunction does not just occur in the late stage of PD.
On the basis of numerous studies, mild cognitive impairment (MCI) is a harbinger of dementia in PD, which is observed as an intermediate state with considerable variability; some patients remain stable and some even revert to normal cognition.
Considered that the timing, profile, and rate of cognitive impairment vary greatly among PD individuals, it is extremely urgent for researchers and clinicians alike to identify and predict future cognitive decline in this population.
Simultaneously, early screening and canonical management of PD with cognitive deficits are very imperative to postpone the disease progression and improve the prognosis of patients.
In our review, we focus on a description of cognitive decline in PD, expound emphatically the pathological mechanisms underlying cognition deficits in PD, then give a comprehensive overview of specific therapeutic strategies, and finally dissect what fresh insights may bring new exciting prospect for the subfield.
American Psychological Association (APA)
Fang, Congcong& Lv, Longqin& Mao, Shanping& Dong, Huimin& Liu, Baohui. 2020. Cognition Deficits in Parkinson’s Disease: Mechanisms and Treatment. Parkinson’s Disease،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1206400
Modern Language Association (MLA)
Fang, Congcong…[et al.]. Cognition Deficits in Parkinson’s Disease: Mechanisms and Treatment. Parkinson’s Disease No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1206400
American Medical Association (AMA)
Fang, Congcong& Lv, Longqin& Mao, Shanping& Dong, Huimin& Liu, Baohui. Cognition Deficits in Parkinson’s Disease: Mechanisms and Treatment. Parkinson’s Disease. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1206400
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206400