Red Raspberry Extract Protects the Skin against UVB-Induced Damage with Antioxidative and Anti-inflammatory Properties
Joint Authors
Wang, Pei-Wen
Cheng, Yu-Chen
Li, Wen-Tai
Wu, Yun-Ru
Pan, Tai-Long
Lee, Chih-Hung
Hung, Y.-C.
Fang, Jia You
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-06
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Extensive exposure to UVB (280–320 nm) is the major risk responsible for various skin injuries.
Numerous reports have shown that natural products could demonstrate photochemopreventive efficacy against UVB damage.
We investigated the preventive effects and associated molecular mechanisms of red raspberry extract upon UVB-caused damage in human epidermal keratinocytes and a nude mouse model.
The protein profiles and immunohistological study on a nude mouse skin indicated that red raspberry extract could prevent UVB-caused cell death and protect the skin against UVB-exposed injury manifested by wrinkling, scaling, tanning, and water loss as well as epidermal thickening.
In addition, red raspberry extract application effectively abolished oxidative damage in DNA and attenuated the carbonylation level of proteins, which attributed to the activation of SOD, Nrf2 and its target genes, and HO-1.
Red raspberry extract also altered the cells’ apoptotic signaling pathways including caspase-3 as well as the inflammatory cascade such as c-jun and attenuated UVB-induced activation of NF-κB and COX-2.
Red raspberry extract could alleviate direct photodamage to the skin caused by UVB exposure through the ROS scavenger and protection against inflammatory responses, which may allow the development of novel strategies in protecting the skin subjected to UVB radiation.
American Psychological Association (APA)
Wang, Pei-Wen& Cheng, Yu-Chen& Hung, Y.-C.& Lee, Chih-Hung& Fang, Jia You& Li, Wen-Tai…[et al.]. 2019. Red Raspberry Extract Protects the Skin against UVB-Induced Damage with Antioxidative and Anti-inflammatory Properties. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1206454
Modern Language Association (MLA)
Wang, Pei-Wen…[et al.]. Red Raspberry Extract Protects the Skin against UVB-Induced Damage with Antioxidative and Anti-inflammatory Properties. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1206454
American Medical Association (AMA)
Wang, Pei-Wen& Cheng, Yu-Chen& Hung, Y.-C.& Lee, Chih-Hung& Fang, Jia You& Li, Wen-Tai…[et al.]. Red Raspberry Extract Protects the Skin against UVB-Induced Damage with Antioxidative and Anti-inflammatory Properties. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1206454
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206454