The Relationship between Side of Onset and Cerebral Regional Homogeneity in Parkinson’s Disease: A Resting-State fMRI Study
Joint Authors
Li, Kai
Zhao, Hong
Li, Chun-Mei
Ma, Xin-Xin
Chen, Min
Li, Shu-Hua
Wang, Rui
Lou, Bao-Hui
Chen, Hai-Bo
Su, Wen
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Motor symptoms are usually asymmetric in Parkinson’s disease (PD), and asymmetry in PD may involve widespread brain areas.
We sought to evaluate the effect of asymmetry on the whole brain spontaneous activity using the measure regional homogeneity (ReHo) through resting-state functional MRI.
Methods.
We recruited 30 PD patients with left onset (LPD), 27 with right side (RPD), and 32 controls with satisfactory data.
Their demographic, clinical, and neuropsychological information were obtained.
Resting-state functional MRI was performed, and ReHo was used to determine the brain activity.
ANCOVA was utilized to analyze between-group differences in ReHo and the associations between abnormal ReHo, and various clinical and neuropsychological variables were explored by Spearman’s correlation.
Results.
LPD patients had higher ReHo in the right temporal pole than the controls.
RPD patients had increased ReHo in the right temporal pole and decreased ReHo in the primary motor cortex and premotor area, compared with the controls.
Directly comparing LPD and RPD patients did not show a significant difference in ReHo.
ReHo of the right temporal pole was significantly correlated with depression and anxiety in RPD patients.
Conclusions.
Both LPD and RPD have increased brain activity synchronization in the right temporal pole, and only RPD has decreased brain activity synchronization in the right frontal motor areas.
The changed brain activity in the right temporal pole may play a compensatory role for depression and anxiety in PD, and the altered cerebral function in the right frontal motor area in RPD may represent the reorganization of the motor system in RPD.
American Psychological Association (APA)
Li, Kai& Zhao, Hong& Li, Chun-Mei& Ma, Xin-Xin& Chen, Min& Li, Shu-Hua…[et al.]. 2020. The Relationship between Side of Onset and Cerebral Regional Homogeneity in Parkinson’s Disease: A Resting-State fMRI Study. Parkinson’s Disease،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1206460
Modern Language Association (MLA)
Li, Kai…[et al.]. The Relationship between Side of Onset and Cerebral Regional Homogeneity in Parkinson’s Disease: A Resting-State fMRI Study. Parkinson’s Disease No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1206460
American Medical Association (AMA)
Li, Kai& Zhao, Hong& Li, Chun-Mei& Ma, Xin-Xin& Chen, Min& Li, Shu-Hua…[et al.]. The Relationship between Side of Onset and Cerebral Regional Homogeneity in Parkinson’s Disease: A Resting-State fMRI Study. Parkinson’s Disease. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1206460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206460