A Study for Expanding Application Sites for Rotigotine Transdermal Patch
Joint Authors
Hattori, Nobutaka
Kujirai, Hitoshi
Itaya, Sakiko
Ono, Yumi
Inaba, Akira
Orimo, Satoshi
Takahashi, Makoto
Shimo, Yasushi
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The rotigotine transdermal patch (RTP) is a dopamine agonist used to treat Parkinson’s disease (PD).
Some PD patients cannot continue RTP treatment due to application site reactions.
We explored sites for RTP where application site reactions are less severe than those in the six approved application sites.
Thirty PD patients (12 men, mean age = 76 years) who underwent RTP at the approved sites and had some application site reactions were enrolled in this study.
When applying the RTP to the approved application sites for more than four weeks (pre-RTP) and then on the shin for the following four weeks (post-RTP), skin reactions, itching evaluated using the skin irritation score, motor symptoms, clinical global impressions scale, and plasma rotigotine concentration were examined.
The mean visual analogue scale and skin irritation score in the post-RTP group were significantly lower than those in the pre-RTP group.
The mean Movement Disorder Society-Unified Parkinson’s Disease Rating Scale part III score in the post-RTP group was slightly but significantly lower than that in the pre-RTP group.
Plasma rotigotine concentration in the post-RTP group was slightly but significantly lower than that in the pre-RTP group.
These results indicate that the shin can be a useful application site for RTP.
American Psychological Association (APA)
Kujirai, Hitoshi& Itaya, Sakiko& Ono, Yumi& Takahashi, Makoto& Inaba, Akira& Shimo, Yasushi…[et al.]. 2020. A Study for Expanding Application Sites for Rotigotine Transdermal Patch. Parkinson’s Disease،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1206473
Modern Language Association (MLA)
Kujirai, Hitoshi…[et al.]. A Study for Expanding Application Sites for Rotigotine Transdermal Patch. Parkinson’s Disease No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1206473
American Medical Association (AMA)
Kujirai, Hitoshi& Itaya, Sakiko& Ono, Yumi& Takahashi, Makoto& Inaba, Akira& Shimo, Yasushi…[et al.]. A Study for Expanding Application Sites for Rotigotine Transdermal Patch. Parkinson’s Disease. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1206473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206473