Urinary Biomarkers of Inflammation and Oxidative Stress Are Elevated in Obese Children and Correlate with a Marker of Endothelial Dysfunction
Joint Authors
Selvaraju, Vaithinathan
Ayine, Priscilla
Fadamiro, Moni
Geetha, Thangiah
Babu, Jeganathan Ramesh
Brown, Michael D.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Obesity is a state of chronic low-level inflammation closely associated with oxidative stress.
Childhood obesity is associated with endothelial dysfunction, inflammation, and oxidative stress markers individually.
This study was aimed at determining the association between the biomarkers of inflammation, oxidative stress, and endothelial dysfunction in urine samples of healthy, overweight, and obese children.
Eighty-eight elementary school children aged between 6 and 10 years participated in this study.
Anthropometric measurements were measured using WHO recommendations.
The biomarkers of low-grade inflammation such as C-reactive protein (CRP), interleukin-6 (IL-6), and α-1-acid glycoprotein (AGP); oxidative stress markers such as 8-isoprostane and 8-hydroxy-2′-deoxyguanosine (8-OHdG); and endothelin-1 (ET-1) were analyzed in urine samples.
The area under the curve (AUC) by the receiver operating characteristics (ROC) was analyzed to identify the best urinary biomarker in childhood obesity.
Linear regression and Pearson correlation were analyzed to determine the association between the parameters.
The obese participants have significantly increased levels of CRP, AGP, IL-6, and 8-isoprostane compared to normal-weight participants.
The overweight participants had significantly increased levels of ET-1 and 8-OHdG but not the obese group compared to the NW group.
The AUC for urinary CRP (AUC: 0.847, 95% CI: 0.765-0.930; p<0.0001) and 8-isoprostane (AUC: 0.857, 95% CI: 0.783-0.932; p<0.0001) showed a greater area under ROC curves compared to other inflammatory and oxidative markers.
The urinary CRP and 8-isoprostane significantly correlated with the obesity measures (body mass index, waist circumference, and waist-to- height ratio) and ET-1, inflammatory, and oxidative markers.
The increased urinary inflammatory markers and 8-isoprostane can serve as a noninvasive benchmark for early detection of the risk of developing cardiovascular disease.
American Psychological Association (APA)
Selvaraju, Vaithinathan& Ayine, Priscilla& Fadamiro, Moni& Babu, Jeganathan Ramesh& Brown, Michael D.& Geetha, Thangiah. 2019. Urinary Biomarkers of Inflammation and Oxidative Stress Are Elevated in Obese Children and Correlate with a Marker of Endothelial Dysfunction. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1206492
Modern Language Association (MLA)
Selvaraju, Vaithinathan…[et al.]. Urinary Biomarkers of Inflammation and Oxidative Stress Are Elevated in Obese Children and Correlate with a Marker of Endothelial Dysfunction. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1206492
American Medical Association (AMA)
Selvaraju, Vaithinathan& Ayine, Priscilla& Fadamiro, Moni& Babu, Jeganathan Ramesh& Brown, Michael D.& Geetha, Thangiah. Urinary Biomarkers of Inflammation and Oxidative Stress Are Elevated in Obese Children and Correlate with a Marker of Endothelial Dysfunction. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1206492
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206492