Nerolidol Suppresses the Inflammatory Response during Lipopolysaccharide-Induced Acute Lung Injury via the Modulation of Antioxidant Enzymes and the AMPKNrf-2HO-1 Pathway
Joint Authors
Ni, Yung-Lun
Shen, Huan-Ting
Su, Chun-Hung
Chen, Wen-Ying
Huang-Liu, Rosa
Chen, Shih-Pin
Kuan, Yu-Hsiang
Chen, Chun-Jung
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Acute lung injury (ALI) is a life-threatening disease that is characterised by the rapid onset of inflammatory responses.
Lipopolysaccharide (LPS) is an endotoxin that plays an important role in triggering ALI via pneumonia and sepsis.
However, no effective therapeutic strategies are currently available to treat ALI.
Nerolidol is an aliphatic sesquiterpene alcohol that is found in the essential oils of many flowers as well as floral plants.
It has been shown to exhibit anti-inflammatory, antioxidant, and anticancer properties.
Herein, we show that nerolidol pretreatment counteracted the histopathological hallmarks in LPS-induced ALI mice.
Indeed, nerolidol pretreatment inhibited LPS-induced alveolar-capillary barrier disruption, lung edema, and lipid peroxidation.
Moreover, nerolidol pretreatment prevented the LPS from decreasing the enzymatic activities of superoxide dismutase, catalase, and glutathione peroxidase.
Importantly, nerolidol treatment enhanced phosphorylation of AMP-activated protein kinase (AMPK) and expression of nuclear factor erythroid-derived 2-related factor 2 (Nrf-2) and heme oxygenase-1 (HO-1).
Taken together, our study reveals the novel protective effects of nerolidol in LPS-induced ALI via the induction of antioxidant responses and activation of the AMPK/Nrf-2/HO-1 signalling pathway.
American Psychological Association (APA)
Ni, Yung-Lun& Shen, Huan-Ting& Su, Chun-Hung& Chen, Wen-Ying& Huang-Liu, Rosa& Chen, Chun-Jung…[et al.]. 2019. Nerolidol Suppresses the Inflammatory Response during Lipopolysaccharide-Induced Acute Lung Injury via the Modulation of Antioxidant Enzymes and the AMPKNrf-2HO-1 Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1206495
Modern Language Association (MLA)
Ni, Yung-Lun…[et al.]. Nerolidol Suppresses the Inflammatory Response during Lipopolysaccharide-Induced Acute Lung Injury via the Modulation of Antioxidant Enzymes and the AMPKNrf-2HO-1 Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1206495
American Medical Association (AMA)
Ni, Yung-Lun& Shen, Huan-Ting& Su, Chun-Hung& Chen, Wen-Ying& Huang-Liu, Rosa& Chen, Chun-Jung…[et al.]. Nerolidol Suppresses the Inflammatory Response during Lipopolysaccharide-Induced Acute Lung Injury via the Modulation of Antioxidant Enzymes and the AMPKNrf-2HO-1 Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1206495
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206495