Antiphotoaging and Antimelanogenic Effects of Penthorum chinense Pursh Ethanol Extract due to Antioxidant- and Autophagy-Inducing Properties
Joint Authors
Jeong, Deok
Kim, Jong-Hoon
Park, Sang Hee
Oh, Junsang
Aravinthan, Adithan
Kim, You Ah
Park, Byoung Jun
Kang, Hakhee
Cho, Jae Youl
Sung, Gi-Ho
Lee, Jongsung
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Ethnopharmacological Relevance.
Penthorum chinense Pursh (Penthoraceae) is a traditional herbal plant that has been used in China for the treatment of jaundice, cholecystitis, edema, and infectious hepatitis.
In addition, the Korea Medicinal Plant Dictionary states that Penthorum chinense Pursh can be used to treat contusions and skin bruises by improving blood flow.
Recent studies have shown that Penthorum chinense Pursh ethanol extract (Pc-EE) exhibits strong antioxidant effects.
In this study, we examined the effects of Pc-EE on UVB-induced or H2O2-induced oxidative stress, as well as its antimelanogenic properties.
Cell viability, matrix metalloproteinase (MMP) expression, cyclooxygenease-2 (COX-2), and interleukin-6 (IL-6) expression and moisturizing factors were investigated in keratinocytes.
Collagen synthesis induction was measured in HEK293T cells.
For melanogenesis, the effects of Pc-EE on melanin content and tyrosinase activity were measured.
Additionally, the antimelanogenic- and autophagy-inducing activities of Pc-EE were examined using immunoblotting and confocal microscopy.
Pc-EE protected HaCaT cells against death from UVB irradiation- or H2O2-induced oxidative stress.
Pc-EE increased the promoter activity of the type 1 procollagen gene Col1A1 and decreased the expression of MMPs, COX-2, IL-6, and hyaluronidase induced by UVB irradiation- or H2O2-induced oxidative stress.
Pc-EE showed a strong antioxidant effect in the DPPH assay.
In α-melanocyte-stimulating hormone- (α-MSH-) stimulated B16F10 cells, Pc-EE reduced melanin production, decreased tyrosinase expression and microphthalmia-associated transcription factor (MITF) protein levels, and decreased the phosphorylation levels of p38 and JNK.
In HEK293T cells, Pc-EE promoted the expression of GFP-LC3B.
In B16F10 cells, the LC3B and melanin contents were reduced by Pc-EE and were restored by the autophagy inhibitor 3-methyladenine (3-MA).
These results suggest that Pc-EE can be used as a skin protection agent due to its antiapoptotic, antiaging, anti-inflammatory, and antimelanogenic properties.
American Psychological Association (APA)
Jeong, Deok& Lee, Jongsung& Park, Sang Hee& Kim, You Ah& Park, Byoung Jun& Oh, Junsang…[et al.]. 2019. Antiphotoaging and Antimelanogenic Effects of Penthorum chinense Pursh Ethanol Extract due to Antioxidant- and Autophagy-Inducing Properties. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1206540
Modern Language Association (MLA)
Jeong, Deok…[et al.]. Antiphotoaging and Antimelanogenic Effects of Penthorum chinense Pursh Ethanol Extract due to Antioxidant- and Autophagy-Inducing Properties. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1206540
American Medical Association (AMA)
Jeong, Deok& Lee, Jongsung& Park, Sang Hee& Kim, You Ah& Park, Byoung Jun& Oh, Junsang…[et al.]. Antiphotoaging and Antimelanogenic Effects of Penthorum chinense Pursh Ethanol Extract due to Antioxidant- and Autophagy-Inducing Properties. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1206540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206540