Comparison between the Interferon γ Release Assay—QuantiFERON Gold Plus (QFT-Plus)—and Tuberculin Skin Test (TST) in the Detection of Tuberculosis Infection in Immunocompromised Children
Joint Authors
Primaturia, Cory
Reniarti, Lelani
Nataprawira, Heda Melinda
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Immunocompromised patients are at a higher risk of having latent tuberculosis infection (LTBI).
QuantiFERON-TB Gold Plus (QFT-Plus) has been proven to perform effectively in LTBI detection among immunocompromised adults and can overcome the limitations of the tuberculin skin test (TST).
However, the role of QFT-Plus in detecting LTBI in immunocompromised paediatric patients has not been well established.
Therefore, the aim of this study was to assess the test agreement between QFT-Plus and the TST in LTBI detection among immunocompromised children.
Method.
In this cross-sectional study, we enrolled immunocompromised paediatric patients, aged between 5 and 18 years, who were treated with corticosteroids and/or chemotherapy from June to November 2019.
We categorized them into three groups based on the following diseases: hematologic malignancies and nephrological and immunological diseases.
We recorded the patient characteristics and QFT-Plus and TST results, in which the positive result of the TST was induration≥5 mm.
Within the same group, comparisons between the two tests were performed using the McNemar test, and results were statistically significant for p values of <0.05.
The kappa index was used to assess the agreement between the two test results.
Results.
Among 71 patients (median age: 11.8 years) who underwent TST and QFT-Plus testing, 52% were females, and 69% had a normal nutritional status.
Chemotherapy was the most common treatment modality for hematologic malignancy compared to other immunosuppressive treatments.
The total number of patients with positive QFT-Plus and TST results was 11/71 (15.5%) and 4/71 (5.6%), respectively, among whom 3/11 patients had positive results in both tests, and one patient with positive TST results exhibited a discrepancy, as this was not followed by positive QFT-Plus results.
QFT-Plus generated more positive results than the TST in immunocompromised children (McNemar, p=0.039 (p<0.05)).
The diagnostic agreement between the tests was fair (K=0.345, 95% CI: 0.05–0.745).
Conclusion.
QFT-Plus detected LTBI more effectively than the TST in immunocompromised children.
American Psychological Association (APA)
Primaturia, Cory& Reniarti, Lelani& Nataprawira, Heda Melinda. 2020. Comparison between the Interferon γ Release Assay—QuantiFERON Gold Plus (QFT-Plus)—and Tuberculin Skin Test (TST) in the Detection of Tuberculosis Infection in Immunocompromised Children. Pulmonary Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1206565
Modern Language Association (MLA)
Primaturia, Cory…[et al.]. Comparison between the Interferon γ Release Assay—QuantiFERON Gold Plus (QFT-Plus)—and Tuberculin Skin Test (TST) in the Detection of Tuberculosis Infection in Immunocompromised Children. Pulmonary Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1206565
American Medical Association (AMA)
Primaturia, Cory& Reniarti, Lelani& Nataprawira, Heda Melinda. Comparison between the Interferon γ Release Assay—QuantiFERON Gold Plus (QFT-Plus)—and Tuberculin Skin Test (TST) in the Detection of Tuberculosis Infection in Immunocompromised Children. Pulmonary Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1206565
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206565