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The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling Network
Joint Authors
Xu, Yulin
Li, Xiang
Chen, Yuanyuan
Zhao, Jidong
Shi, Jiayuan
Wang, Mingfang
Qiu, Shuang
Hu, Yinghui
Cui, Yanfang
Liu, Chunrong
Liu, Changlin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-18
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Multiple signaling pathways including ERK, PI3K-Akt, and NF-κB, which are essential for onset and development of cancer, can be activated by intracellularly sustained high levels of H2O2 provided by elevated activity and expression of copper/zinc superoxide dismutase (SOD1) that catalyzes the dismutation of O2•− into H2O2.
Here, tests performed by the utilization of our designed specific SOD1 inhibitor LD100 on cancer and normal cells reveal that the signaling pathways and their crosstalk to support cancer cell growth are repressed, but the signaling pathways to promote cancer cell cycle arrest and apoptosis are stimulated by specific SOD1 inhibition-mediated ROS changes.
These regulated pathways constitute an ROS signaling network that determines the fate of cancer cells.
This ROS signaling network is also regulated in SOD1 knockdown cells.
These findings might facilitate disclosure of action mechanisms by copper-chelating anticancer agents and design of SOD1-targeting and ROS signaling pathway-interfering anticancer small molecules.
American Psychological Association (APA)
Li, Xiang& Chen, Yuanyuan& Zhao, Jidong& Shi, Jiayuan& Wang, Mingfang& Qiu, Shuang…[et al.]. 2019. The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling Network. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-21.
https://search.emarefa.net/detail/BIM-1206579
Modern Language Association (MLA)
Li, Xiang…[et al.]. The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling Network. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-21.
https://search.emarefa.net/detail/BIM-1206579
American Medical Association (AMA)
Li, Xiang& Chen, Yuanyuan& Zhao, Jidong& Shi, Jiayuan& Wang, Mingfang& Qiu, Shuang…[et al.]. The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling Network. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-21.
https://search.emarefa.net/detail/BIM-1206579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206579