Integrating Literature-Based Knowledge Database and Expression Data to Explore Molecular Pathways Connecting PPARG and Myocardial Infarction
Joint Authors
Cao, Rongyuan
Dong, Yan
Kural, Kamil Can
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptor γ (PPARG) might play a protective role in the development of myocardial infarction (MI) with limited mechanisms identified.
Genes associated with both PPARG and MI were extracted from Elsevier Pathway Studio to construct the initial network.
The gene expression activity within the network was estimated through a mega-analysis with eight independent expression datasets derived from Gene Expression Omnibus (GEO) to build PPARG and MI connecting pathways.
After that, gene set enrichment analysis (GSEA) was conducted to explore the functional profile of the genes involved in the PPARG-driven network.
PPARG demonstrated a significantly low expression in MI patients (LFC=−0.52; p<1.84e−9).
Consequently, PPARG could indicatively be promoting three MI inhibitors (e.g., SOD1, CAV1, and POU5F1) and three MI-downregulated markers (e.g., ALB, ACADM, and ADIPOR2), which were deactivated in MI cases (p<0.05), and inhibit two MI-upregulated markers (RELA and MYD88), which showed increased expression levels in MI cases (p=0.0077 and 0.047, respectively).
These eight genes were mainly enriched in nutrient- and cell metabolic-related pathways and functionally linked by GSEA and PPCN.
Our results suggest that PPARG could protect the heart against both the development and progress of MI through the regulation of nutrient- and metabolic-related pathways.
American Psychological Association (APA)
Cao, Rongyuan& Dong, Yan& Kural, Kamil Can. 2020. Integrating Literature-Based Knowledge Database and Expression Data to Explore Molecular Pathways Connecting PPARG and Myocardial Infarction. PPAR Research،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1206588
Modern Language Association (MLA)
Cao, Rongyuan…[et al.]. Integrating Literature-Based Knowledge Database and Expression Data to Explore Molecular Pathways Connecting PPARG and Myocardial Infarction. PPAR Research No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1206588
American Medical Association (AMA)
Cao, Rongyuan& Dong, Yan& Kural, Kamil Can. Integrating Literature-Based Knowledge Database and Expression Data to Explore Molecular Pathways Connecting PPARG and Myocardial Infarction. PPAR Research. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1206588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206588