PPARD May Play a Protective Role against the Development of Schizophrenia
Joint Authors
Xu, Yong
Li, Xinrong
Liu, Sha
Kapoor, Karan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
PPARD has been suggested to contribute to the etiology of schizophrenia (SCZ) with the underlying mechanisms largely unknown.
Here, we first collected and analyzed the PPARD expression profile from three groups: (1) 18 healthy control (HC) subjects, (2) 14 clinical high-risk (CHR) patients, and (3) 19 early onset of SCZ (EOS) patients.
After that, we conducted a systematical pathway analysis to explore the potential mechanisms involved in PPARD exerting influence on the pathological development of SCZ.
Compared to the HC group, the expression of PPARD was slightly decreased in the EOS group (LFC=−0.34; p=0.23) and increased in the CHR group (LFC=0.65; p=0.20).
However, there was a significant difference between the EOS group and the CHR group (LFC=−0.99; p=0.015), reflecting the amount of variation in PPARD expression before and after the onset of SCZ.
Pathway analysis suggested that overexpression of PPARD may regulate ten proteins or molecules to inhibit the pathological development of SCZ, including the deactivation of eight SCZ promoters and stimulation of two SCZ inhibitors.
Our results support the association between PPARD and SCZ.
The pathways identified may help in the understanding of the potential mechanisms by which PPARD contributes to the etiology of SCZ.
American Psychological Association (APA)
Li, Xinrong& Liu, Sha& Kapoor, Karan& Xu, Yong. 2020. PPARD May Play a Protective Role against the Development of Schizophrenia. PPAR Research،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1206596
Modern Language Association (MLA)
Li, Xinrong…[et al.]. PPARD May Play a Protective Role against the Development of Schizophrenia. PPAR Research No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1206596
American Medical Association (AMA)
Li, Xinrong& Liu, Sha& Kapoor, Karan& Xu, Yong. PPARD May Play a Protective Role against the Development of Schizophrenia. PPAR Research. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1206596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206596