The Emerging Role of PPAR BetaDelta in Tumor Angiogenesis
Joint Authors
Wagner, Kay-Dietrich
Wagner, Nicole
Du, Siyue
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-13
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
PPARs are ligand-activated transcriptional factors that belong to the nuclear receptor superfamily.
Among them, PPAR alpha and PPAR gamma are prone to exert an antiangiogenic effect, whereas PPAR beta/delta has an opposite effect in physiological and pathological conditions.
Angiogenesis has been known as a hallmark of cancer, and our recent works also demonstrate that vascular-specific PPAR beta/delta overexpression promotes tumor angiogenesis and progression in vivo.
In this review, we will mainly focus on the role of PPAR beta/delta in tumor angiogenesis linked to the tumor microenvironment to further facilitate tumor progression and metastasis.
Moreover, the crosstalk between PPAR beta/delta and its downstream key signal molecules involved in tumor angiogenesis will also be discussed, and the network of interplay between them will further be established in the review.
American Psychological Association (APA)
Du, Siyue& Wagner, Nicole& Wagner, Kay-Dietrich. 2020. The Emerging Role of PPAR BetaDelta in Tumor Angiogenesis. PPAR Research،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1206599
Modern Language Association (MLA)
Du, Siyue…[et al.]. The Emerging Role of PPAR BetaDelta in Tumor Angiogenesis. PPAR Research No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1206599
American Medical Association (AMA)
Du, Siyue& Wagner, Nicole& Wagner, Kay-Dietrich. The Emerging Role of PPAR BetaDelta in Tumor Angiogenesis. PPAR Research. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1206599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206599