PPARs and the Development of Type 1 Diabetes
Joint Authors
Buschard, K.
Haupt-Jorgensen, Martin
Holm, Laurits J.
Mønsted, Mia Øgaard
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptors (PPARs) are a family of transcription factors with a key role in glucose and lipid metabolism.
PPARs are expressed in many cell types including pancreatic beta cells and immune cells, where they regulate insulin secretion and T cell differentiation, respectively.
Moreover, various PPAR agonists prevent diabetes in the non-obese diabetic (NOD) mouse model of type 1 diabetes.
PPARs are thus of interest in type 1 diabetes (T1D) as they represent a novel approach targeting both the pancreas and the immune system.
In this review, we examine the role of PPARs in immune responses and beta cell biology and their potential as targets for treatment of T1D.
American Psychological Association (APA)
Holm, Laurits J.& Mønsted, Mia Øgaard& Haupt-Jorgensen, Martin& Buschard, K.. 2020. PPARs and the Development of Type 1 Diabetes. PPAR Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1206617
Modern Language Association (MLA)
Holm, Laurits J.…[et al.]. PPARs and the Development of Type 1 Diabetes. PPAR Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1206617
American Medical Association (AMA)
Holm, Laurits J.& Mønsted, Mia Øgaard& Haupt-Jorgensen, Martin& Buschard, K.. PPARs and the Development of Type 1 Diabetes. PPAR Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1206617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206617
