The Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Pan-Cancer
Joint Authors
Huang, Ling
Zhang, Jiaqi
Hu, Peng
Zhang, Jiaxin
Zhu, Xiaolong
Huang, Runzhi
Li, Mingxiao
Yan, Penghui
Yin, Huabin
Zhai, Suna
Sun, Zehui
Meng, Tong
Yang, Daoke
Huang, Zongqiang
Li, Man
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-22
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptors (PPARs) are members of nuclear transcription factors.
The functions of the PPAR family (PPARA, PPARD, and PPARG) and their coactivators (PPARGC1A and PPARGC1B) in maintenance of lipid and glucose homeostasis have been unveiled.
However, the roles of PPARs in cancer development remain elusive.
In this work, we made use of 11,057 samples across 33 TCGA tumor types to analyze the relationship between PPAR transcriptional expression and tumorigenesis as well as drug sensitivity.
We performed multidimensional analyses on PPARA, PPARG, PPARD, PPARGC1A, and PPARGC1B, including differential expression analysis in pan-cancer, immune subtype analysis, clinical analysis, tumor purity analysis, stemness correlation analysis, and drug responses.
PPARs and their coactivators expressed differently in different types of cancers, in different immune subtypes.
This analysis reveals various expression patterns of the PPAR family at a level of pan-cancer and provides new clues for the therapeutic strategies of cancer.
American Psychological Association (APA)
Huang, Runzhi& Zhang, Jiaqi& Li, Mingxiao& Yan, Penghui& Yin, Huabin& Zhai, Suna…[et al.]. 2020. The Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Pan-Cancer. PPAR Research،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1206622
Modern Language Association (MLA)
Huang, Runzhi…[et al.]. The Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Pan-Cancer. PPAR Research No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1206622
American Medical Association (AMA)
Huang, Runzhi& Zhang, Jiaqi& Li, Mingxiao& Yan, Penghui& Yin, Huabin& Zhai, Suna…[et al.]. The Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Pan-Cancer. PPAR Research. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1206622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206622