Bergenin Attenuates Hepatic Fibrosis by Regulating Autophagy Mediated by the PPAR-γTGF-β Pathway
Joint Authors
Xia, Yujing
Li, Jingjing
Chen, Kan
Feng, Jiao
Guo, Chuanyong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Liver fibrosis is a pathological process involving diffuse extracellular matrix (ECM) deposition in the liver.
It is typical of many chronic liver diseases, including cirrhosis, and effective drugs are needed.
In this study, we explored the protective effect of bergenin on liver fibrosis induced by carbon tetrachloride and bile duct ligation.
A variety of molecular biological methods (qRT-PCR, western blotting, and immunohistochemistry) were employed to confirm the increased degree of hepatocyte injury and ECM formation in the disease model, consistent with autophagy and activation of the TGF-β pathway.
Bergenin activated PPAR-γ and inhibited TGF-β and autophagy and decreased liver fibrosis by inhibiting hepatocyte necrosis and ECM formation in a dose-dependent manner.
The results suggest that bergenin may be a promising drug candidate for the treatment of liver fibrosis.
American Psychological Association (APA)
Xia, Yujing& Li, Jingjing& Chen, Kan& Feng, Jiao& Guo, Chuanyong. 2020. Bergenin Attenuates Hepatic Fibrosis by Regulating Autophagy Mediated by the PPAR-γTGF-β Pathway. PPAR Research،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1206630
Modern Language Association (MLA)
Xia, Yujing…[et al.]. Bergenin Attenuates Hepatic Fibrosis by Regulating Autophagy Mediated by the PPAR-γTGF-β Pathway. PPAR Research No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1206630
American Medical Association (AMA)
Xia, Yujing& Li, Jingjing& Chen, Kan& Feng, Jiao& Guo, Chuanyong. Bergenin Attenuates Hepatic Fibrosis by Regulating Autophagy Mediated by the PPAR-γTGF-β Pathway. PPAR Research. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1206630
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206630