Nitric Oxide Mediates Inflammation in Type II Diabetes Mellitus through the PPARγeNOS Signaling Pathway
Joint Authors
Zhou, Lin
Yuan, Haipo
Guo, Hua
Zhang, Qinglan
Li, Fang-fang
Wang, Sheng-Ming
Shi, Gang
Wang, Maojuan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Inflammation accounts for the process of type II diabetes mellitus (T2DM), the specific mechanism of which is still to be elucidated yet.
Nitric oxide (NO), a critical inflammation regulator, the role of which is the inflammation of T2DM, is rarely reported.
Therefore, our study is aimed at exploring the effect of NO on the inflammation in T2DM and the corresponding mechanism.
We analyzed the NO levels in plasma samples from T2DM patients and paired healthy adults by Nitric Oxide Analyzer then measured the expression of inflammatory cytokines (C-reactive protein, heptoglobin, IL-1β, TNF-α, IL-6) in insulin-induced HepG2 cells treated with NO donor or NO scavenger, and the PPARγ, eNOS, C-reactive protein, heptoglobin, IL-1β, TNF-α, and IL-6 levels were detected by RT-PCR and western blot in insulin-induced HepG2 cells transfected with si-PPARγ.
The results showed that excess NO increased the inflammation marker levels in T2DM, which is activated by the PPARγ/eNOS pathway.
These findings will strengthen the understanding of NO in T2DM and provide a new target for the treatment of T2DM.
American Psychological Association (APA)
Guo, Hua& Zhang, Qinglan& Yuan, Haipo& Zhou, Lin& Li, Fang-fang& Wang, Sheng-Ming…[et al.]. 2020. Nitric Oxide Mediates Inflammation in Type II Diabetes Mellitus through the PPARγeNOS Signaling Pathway. PPAR Research،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1206645
Modern Language Association (MLA)
Guo, Hua…[et al.]. Nitric Oxide Mediates Inflammation in Type II Diabetes Mellitus through the PPARγeNOS Signaling Pathway. PPAR Research No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1206645
American Medical Association (AMA)
Guo, Hua& Zhang, Qinglan& Yuan, Haipo& Zhou, Lin& Li, Fang-fang& Wang, Sheng-Ming…[et al.]. Nitric Oxide Mediates Inflammation in Type II Diabetes Mellitus through the PPARγeNOS Signaling Pathway. PPAR Research. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1206645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206645