Isoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells
Joint Authors
Li, Defang
Zheng, Qiusheng
Liu, Xiaona
Hao, Wenjin
Pan, Zhaohai
Chen, Xiaoyu
Ren, Huan-Huan
Wang, Dan
Chen, Ying
Qu, Chuan-Jun
Xu, Wen-Juan
Wang, Ke-Jun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The mitochondrial protein mitoNEET is a type of iron-sulfur protein localized to the outer membrane of mitochondria and is involved in a variety of human pathologies including cystic fibrosis, diabetes, muscle atrophy, and neurodegeneration.
In the current study, we found that isoliquiritigenin (ISL), one of the components of the root of Glycyrrhiza glabra L., could decrease the expression of mitoNEET in A375 melanoma cells.
We also demonstrated that mitoNEET could regulate the content of reactive oxygen species (ROS), by showing that the ISL-mediated increase in the cellular ROS content could be mitigated by the mitoNEET overexpression.
We also confirmed the important role of ROS in ISL-treated A375 cells.
The increased apoptosis rate and the decreased mitochondrial membrane potential were mitigated by the overexpression of mitoNEET in A375 cells.
These findings indicated that ISL could decrease the expression of mitoNEET, which regulated ROS content and subsequently induced mitochondrial dysfunction and apoptosis in A375 cells.
Our findings also highlight mitoNEET as a promising mitochondrial target for cancer therapy.
American Psychological Association (APA)
Chen, Xiaoyu& Ren, Huan-Huan& Wang, Dan& Chen, Ying& Qu, Chuan-Jun& Pan, Zhaohai…[et al.]. 2019. Isoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1206651
Modern Language Association (MLA)
Chen, Xiaoyu…[et al.]. Isoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1206651
American Medical Association (AMA)
Chen, Xiaoyu& Ren, Huan-Huan& Wang, Dan& Chen, Ying& Qu, Chuan-Jun& Pan, Zhaohai…[et al.]. Isoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1206651
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206651