Analgesic Mechanism of Sinomenine against Chronic Pain
Joint Authors
Jiang, Jian-Dong
Gao, Tianle
Li, Tao
Jiang, Wei
Fan, Weiming
Yin, Zhenming
Guo, Huihui
Wang, Lulu
Han, Yanxing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purified from the roots of the plant Sinomenium acutum, sinomenine is traditionally used in China and Japan for treating rheumatism and arthritis.
Previously, we have demonstrated that sinomenine possessed a broad analgesic spectrum in various chronic pain animal models and repeated administration of sinomenine did not generate tolerance.
In this review article, we discussed sinomenine’s analgesic mechanism with focus on its role on immune regulation and neuroimmune interaction.
Sinomenine has distinct immunoregulative properties, in which glutamate, adenosine triphosphate, nitric oxide, and proinflammatory cytokines are thought to be involved.
Sinomenine may alter the unbalanced neuroimmune interaction and inhibit neuroinflammation, oxidative stress, and central sensitization in chronic pain states.
In conclusion, sinomenine has promising potential for chronic pain management in different clinical settings.
American Psychological Association (APA)
Jiang, Wei& Fan, Weiming& Gao, Tianle& Li, Tao& Yin, Zhenming& Guo, Huihui…[et al.]. 2020. Analgesic Mechanism of Sinomenine against Chronic Pain. Pain Research and Management،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1206725
Modern Language Association (MLA)
Jiang, Wei…[et al.]. Analgesic Mechanism of Sinomenine against Chronic Pain. Pain Research and Management No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1206725
American Medical Association (AMA)
Jiang, Wei& Fan, Weiming& Gao, Tianle& Li, Tao& Yin, Zhenming& Guo, Huihui…[et al.]. Analgesic Mechanism of Sinomenine against Chronic Pain. Pain Research and Management. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1206725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206725