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Emotional Processing Impairments in Apathetic Patients with Parkinson’s Disease: An ERP Study in Early Time Windows
Joint Authors
Wei, Wei
Ruan, Jianghai
Duan, Xiaodong
Luo, Hua
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We investigated emotional processing in apathetic patients with Parkinson’s disease (PD) by observing components of event-related potentials (ERPs) in early time windows.
Forty PD patients and 21 healthy controls (HCs) were enrolled.
The Starkstein Apathy Scale (SAS) was used to divide the PD patients into apathetic and nonapathetic groups.
Cognitive function was evaluated by the forward and backward Digit Span tests, Trail Making Test (TMT), and Word Fluency Test.
The participants were required to recognize positive, neutral, and negative emotional faces and engage in an emotion categorization task while EEG was recorded.
The time to completion for the TMT (Part A and Part B) from highest to lowest was in the order of apathetic group > nonapathetic group > HC group.
Compared with the nonapathetic and HC groups, in the apathetic group, P100 amplitudes were smaller for positive expressions in the right hemisphere and latencies were longer for positive expressions in the left hemisphere, while latencies were longer for neutral expressions bilaterally.
Compared with the nonapathetic group, in the apathetic group, N170 amplitudes were attenuated and latencies were delayed for neutral and negative expressions in the right hemisphere.
A trend towards larger N170 amplitudes in the right hemisphere than in the left was observed in the nonapathetic and HC groups, but this difference was not significant in the apathetic group.
In the apathetic group, bilateral P100 amplitudes elicited by negative expressions were negatively correlated with SAS scores, and SAS scores were positively correlated with Part B of the TMT.
N170 amplitudes elicited by negative expressions in the right hemisphere were negatively correlated with SAS in the apathetic group and with Part B of TMT in both PD groups.
Our findings suggested that emotional processing was impaired in apathetic PD patients and that the right hemisphere was more sensitive to reflecting this impairment in the early time windows of ERPs.
American Psychological Association (APA)
Wei, Wei& Ruan, Jianghai& Duan, Xiaodong& Luo, Hua. 2019. Emotional Processing Impairments in Apathetic Patients with Parkinson’s Disease: An ERP Study in Early Time Windows. Parkinson’s Disease،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1206825
Modern Language Association (MLA)
Wei, Wei…[et al.]. Emotional Processing Impairments in Apathetic Patients with Parkinson’s Disease: An ERP Study in Early Time Windows. Parkinson’s Disease No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1206825
American Medical Association (AMA)
Wei, Wei& Ruan, Jianghai& Duan, Xiaodong& Luo, Hua. Emotional Processing Impairments in Apathetic Patients with Parkinson’s Disease: An ERP Study in Early Time Windows. Parkinson’s Disease. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1206825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206825