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Relationship between Pain Behavior and Changes in KCNA2 Expression in the Dorsal Root Ganglia of Rats with Osteoarthritis
Joint Authors
Deng, Xiaoming
Zhao, Qihong
Fan, Lei
Wang, Jiafeng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To investigate the relationship between pain behavior and potassium voltage-gated channel subfamily A member 2 (KCNA2) expression in dorsal root ganglia (DRGs) of rats with osteoarthritis (OA).
Methods.
Male Sprague-Dawley rats were randomly divided into three groups: blank control group (group C), normal saline group (group S), and group OA.
Paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL) were measured one day before injection and one, two, four, and six weeks after injection.
At one, two, four, and six weeks after injection, pathological knee joint changes and activated transcription factor-3 (ATF-3) and KCNA2 expressions in DRGs were analyzed.
Results.
Compared with preinjection, PWMT and PWTL at two, four, and six weeks after injection were significantly decreased in the group OA (P<0.05 or 0.01).
Compared with group C, PWMT and PWTL at two, four, and six weeks after injection were significantly decreased in the group OA (P<0.05 or 0.01).
In the group OA, slight local articular cartilage surface destruction was found at week one.
The cartilage surface destruction gradually developed, and the exacerbation of cartilage matrix reduction and bone hyperplasia were increasingly aggravated and eventually evolved into advanced OA in the second to sixth weeks.
Compared with group C, ATF-3 expression was significantly increased, and KCNA2 expression was significantly decreased in the group OA at two, four, and six weeks after injection (P<0.05 or 0.01).
Compared to baseline, ATF-3 expression was significantly increased, and KCNA2 expression was significantly decreased in the group OA (P<0.05 or 0.01).
Conclusion.
Pain behavior in OA rats was associated with decreased KCNA2 expression in DRGs.
American Psychological Association (APA)
Zhao, Qihong& Fan, Lei& Wang, Jiafeng& Deng, Xiaoming. 2020. Relationship between Pain Behavior and Changes in KCNA2 Expression in the Dorsal Root Ganglia of Rats with Osteoarthritis. Pain Research and Management،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1206829
Modern Language Association (MLA)
Zhao, Qihong…[et al.]. Relationship between Pain Behavior and Changes in KCNA2 Expression in the Dorsal Root Ganglia of Rats with Osteoarthritis. Pain Research and Management No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1206829
American Medical Association (AMA)
Zhao, Qihong& Fan, Lei& Wang, Jiafeng& Deng, Xiaoming. Relationship between Pain Behavior and Changes in KCNA2 Expression in the Dorsal Root Ganglia of Rats with Osteoarthritis. Pain Research and Management. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1206829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206829