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The Association between DRD3 Ser9Gly Polymorphism and Depression Severity in Parkinson’s Disease
Joint Authors
Zhi, Yan
Yuan, Yongsheng
Si, Qianqian
Wang, Min
Shen, Yuting
Wang, Lina
Zhang, Hui
Zhang, Kezhong
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
More and more evidence suggests that dopamine receptor D3 gene (DRD3) plays an important role in the clinical manifestations and the treatment of Parkinson’s disease (PD).
DRD3 Ser9Gly polymorphism is the most frequently studied variant point.
Our aim was to investigate the potential effect of DRD3 Ser9Gly polymorphism on modulating resting-state brain function and associative clinical manifestations in PD patients.
We consecutively recruited 61 idiopathic PD patients and 47 healthy controls (HC) who were evaluated by clinical scales, genotyped for variant Ser9Gly in DRD3, and underwent resting-state functional magnetic resonance imaging.
Based on DRD3 Ser9Gly polymorphism, PD patients and HCs were divided into four subgroups.
Then, two-way analysis of covariance (ANCOVA) was applied to investigate main effects and interactions of PD and DRD3 Ser9Gly polymorphism on the brain function via amplitude of low-frequency fluctuations (ALFF) approach.
The association between DRD3 Ser9Gly-modulated significantly different brain regions, and clinical manifestations were detected by Spearman’s correlations.
PD patients exhibited decreased ALFF values in the right inferior occipital gyrus, lingual gyrus, and fusiform gyrus.
A significant difference in the interaction of “groups × genotypes” was observed in the right medial frontal gyrus.
The ALFF value of the cluster showing significant interactions was positively correlated with HAMD-17 scores (r=0.489, p=0.011) and anhedonia scores (r=0.512, p=0.008) in PD patients with the Ser/Gly or Gly/Gly genotypes.
Therefore, D3 gene Ser9Gly polymorphism might be associated with the severity of depression characterized by anhedonia in PD patients.
American Psychological Association (APA)
Zhi, Yan& Yuan, Yongsheng& Si, Qianqian& Wang, Min& Shen, Yuting& Wang, Lina…[et al.]. 2019. The Association between DRD3 Ser9Gly Polymorphism and Depression Severity in Parkinson’s Disease. Parkinson’s Disease،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1206833
Modern Language Association (MLA)
Zhi, Yan…[et al.]. The Association between DRD3 Ser9Gly Polymorphism and Depression Severity in Parkinson’s Disease. Parkinson’s Disease No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1206833
American Medical Association (AMA)
Zhi, Yan& Yuan, Yongsheng& Si, Qianqian& Wang, Min& Shen, Yuting& Wang, Lina…[et al.]. The Association between DRD3 Ser9Gly Polymorphism and Depression Severity in Parkinson’s Disease. Parkinson’s Disease. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1206833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206833