VGLUT2Cdk5p25 Signaling Pathway Contributed to Inflammatory Pain by Complete Freund’s Adjuvant
Joint Authors
Yuwen, Tang
Sun, Jianliang
Feng, Zhiying
Peng, Zhiyou
Tao, Shoujun
Wang, Wenyuan
Guo, Xuejiao
Liu, Gonglu
Luo, Xianzhe
Chen, Yuan
Shen, Yue
Ma, Haixiang
Xu, Peng
Li, Qinghua
Zhang, Honghai
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Vesicular glutamate transporter type 2 (VGLUT2) is known to play an important role in mediating heat hyperalgesia induced by inflammation.
However, the underlying mechanism for this activity is poorly understood.
Cyclin-dependent kinase 5 (Cdk5), serving as a key regulator in modulating release of glutamate, acted a key player in the formation of heat hyperalgesia of inflammatory pain.
However, it remains unknown whether there is a bridge between Cdk5 and VGLUT2 for mediating inflammatory pain.
Therefore, we designed the experiment to determine whether VGLUT2 signaling pathway is involved in inflammatory pain mediated by Cdk5 in the inflammatory pain model induced by complete Freund’s adjuvant (CFA).
Our results showed that the coexpression of Cdk5/VGLUT2 in small- and medium-sized neuronal cells of the dorsal root ganglion (DRG) and spinal cord between days 1 and 3 following subcutaneous injection of CFA was significantly increased.
Moreover, our study revealed that the expression of VGLUT2 protein in the DRG and spinal cord was remarkably increased between days 1 and 3 following CFA injection and was significantly reduced by roscovitine, a selective antagonist of Cdk5.
Additionally, p25 but not p35, an activator of Cdk5, protein was significantly increased by CFA and reduced by roscovitine.
Our findings suggested that VGLUT2/Cdk5 signaling pathway contributes to inflammatory pain mediated by Cdk5/p25.
American Psychological Association (APA)
Yuwen, Tang& Peng, Zhiyou& Tao, Shoujun& Sun, Jianliang& Wang, Wenyuan& Guo, Xuejiao…[et al.]. 2020. VGLUT2Cdk5p25 Signaling Pathway Contributed to Inflammatory Pain by Complete Freund’s Adjuvant. Pain Research and Management،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1206837
Modern Language Association (MLA)
Yuwen, Tang…[et al.]. VGLUT2Cdk5p25 Signaling Pathway Contributed to Inflammatory Pain by Complete Freund’s Adjuvant. Pain Research and Management No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1206837
American Medical Association (AMA)
Yuwen, Tang& Peng, Zhiyou& Tao, Shoujun& Sun, Jianliang& Wang, Wenyuan& Guo, Xuejiao…[et al.]. VGLUT2Cdk5p25 Signaling Pathway Contributed to Inflammatory Pain by Complete Freund’s Adjuvant. Pain Research and Management. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1206837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206837