MicroRNAs: Game Changers in the Regulation of α-Synuclein in Parkinson’s Disease
Joint Authors
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Parkinson’s disease (PD) is the second most common neurodegenerative disorder.
Its neuropathological hallmarks include neuronal loss in the substantia nigra pars compacta (SNpc) and the presence of Lewy bodies containing aggregates of α-synuclein (α-syn).
An imbalance between the rates of α-syn synthesis, aggregation, and clearance can result in abnormal α-syn levels and contribute to the pathogenesis of PD.
MicroRNAs (miRNAs) are endogenous single-stranded noncoding RNAs (∼22 nucleotides) that have recently emerged as key posttranscriptional regulators of gene expression.
In this review, we summarize the functions of miRNAs that directly target α-syn.
We also review miRNAs that indirectly impact α-syn levels or toxicity through different pathways, including those involved in the clearance of α-syn and neuroinflammation.
American Psychological Association (APA)
Zhao, Liang& Wang, Zhiqin. 2019. MicroRNAs: Game Changers in the Regulation of α-Synuclein in Parkinson’s Disease. Parkinson’s Disease،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1206838
Modern Language Association (MLA)
Zhao, Liang& Wang, Zhiqin. MicroRNAs: Game Changers in the Regulation of α-Synuclein in Parkinson’s Disease. Parkinson’s Disease No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1206838
American Medical Association (AMA)
Zhao, Liang& Wang, Zhiqin. MicroRNAs: Game Changers in the Regulation of α-Synuclein in Parkinson’s Disease. Parkinson’s Disease. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1206838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206838