Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County
Joint Authors
Mielke, Michelle M.
Savica, Rodolfo
Hasan, Shemonti
Ahlskog, J. Eric
Bower, James
Turcano, Pierpaolo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Autonomic symptoms are common in α-synuclein disorders: multiple system atrophy (MSA), Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and Parkinson’s disease with dementia (PDD).
These symptoms may precede the motor findings/clinical diagnosis by years.
Erectile dysfunction (ED) is an autonomic symptom that has rarely been studied in these α-synuclein disorders.
In this population-based, case-control study, we investigated the association between premonitory erectile dysfunction surfacing prior to the clinical-motor manifestations of these α-synucleinopathies.
Methods.
We used the medical record-linkage system of the Rochester Epidemiology Project to identify cases of α-synucleinopathies in Olmsted County from 1991 to 2010.
Each male case was matched by age (±1 year) of symptom onset and sex to a control.
We reviewed complete medical records of cases and controls to detect erectile dysfunction prior to the clinical-motor onset of α-synucleinopathies of any type.
We used conditional logistic regression to calculate the odds ratio of all α-synucleinopathies, as well as by type, adjusting for diabetes, coffee, and smoking.
Results.
A history of male erectile dysfunction was associated with 1.5-fold increased odds of an α-synucleinopathy diagnosis of any type in univariate analyses (p=0.06).
When stratifying α-synucleinopathies by type, early erectile dysfunction was most frequent in MSA cases than matched controls (45% vs.
9%).
Premotor phase ED was next most frequent among the DLB cases (46% vs.
27% among the controls; OR = 2.83, p=0.03; when adjusted for diabetes, smoking, and coffee, OR = 2.98, p=0.04).
Premotor phase ED was not significantly associated with PD or PDD.
Conclusions.
Early erectile dysfunction may be a premotor symptom of MSA and DLB, reflecting premonitory dysautonomia.
It was not associated with premotor PD or PDD.
American Psychological Association (APA)
Hasan, Shemonti& Mielke, Michelle M.& Ahlskog, J. Eric& Bower, James& Turcano, Pierpaolo& Savica, Rodolfo. 2019. Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County. Parkinson’s Disease،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1206958
Modern Language Association (MLA)
Hasan, Shemonti…[et al.]. Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County. Parkinson’s Disease No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1206958
American Medical Association (AMA)
Hasan, Shemonti& Mielke, Michelle M.& Ahlskog, J. Eric& Bower, James& Turcano, Pierpaolo& Savica, Rodolfo. Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County. Parkinson’s Disease. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1206958
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206958