How to Choose Platelet-Rich Plasma or Hyaluronic Acid for the Treatment of Knee Osteoarthritis in Overweight or Obese Patients: A Meta-Analysis
Joint Authors
Gao, Fuqiang
Luo, Pan
Xiong, Zhencheng
Sun, Wei
Shi, Lijun
Li, Zirong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
The purpose of this meta-analysis was to determine whether platelet-rich plasma (PRP) was better than hyaluronic acid (HA) for the treatment of knee osteoarthritis (OA) in overweight or obese patients.
Design.
Two reviewers independently used the keywords combined with free words to search English-based electronic databases according to Cochrane Collaboration guidelines, such as PubMed, Embase, ScienceDirect, and Cochrane library.
The pooled data were analyzed using RevMan 5.3.
Results.
Ten randomized controlled trials (RCTs) with 1096 patients were included.
During the first two months of follow-up, there was no significant difference between the two groups.
At the 3rd, 6th, and 12th months of follow-up, the pooled analysis showed that PRP was better than HA for the treatment of knee OA in overweight or obese patients.
There were significant differences between the two groups at Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total score (3 months: MD = −1.35, [95% CI: −2.19 to −0.50], P=0.002, I2 = 0%; 6 months: MD = −7.62, [95% CI: −13.51 to −1.72], P=0.01, I2 = 88%; 12 months: MD = −12.11, [95% CI: −20.21 to −4.01], P=0.003, I2 = 94%).
Conclusions.
For overweight or obese patients with knee OA, intra-articular injection of PRP in a short time was not necessarily superior to HA, but long-term use was better than HA in pain and functional relief.
American Psychological Association (APA)
Luo, Pan& Xiong, Zhencheng& Sun, Wei& Shi, Lijun& Gao, Fuqiang& Li, Zirong. 2020. How to Choose Platelet-Rich Plasma or Hyaluronic Acid for the Treatment of Knee Osteoarthritis in Overweight or Obese Patients: A Meta-Analysis. Pain Research and Management،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1206996
Modern Language Association (MLA)
Luo, Pan…[et al.]. How to Choose Platelet-Rich Plasma or Hyaluronic Acid for the Treatment of Knee Osteoarthritis in Overweight or Obese Patients: A Meta-Analysis. Pain Research and Management No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1206996
American Medical Association (AMA)
Luo, Pan& Xiong, Zhencheng& Sun, Wei& Shi, Lijun& Gao, Fuqiang& Li, Zirong. How to Choose Platelet-Rich Plasma or Hyaluronic Acid for the Treatment of Knee Osteoarthritis in Overweight or Obese Patients: A Meta-Analysis. Pain Research and Management. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1206996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206996