Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson’s Disease

Joint Authors

Park, Jin-Woo
Lee, Chan-Nyoung
Sim, Youngbo
Ham, Hyung-Kyu
Tae, Woo-Suk
Kim, Byung-Jo

Source

Parkinson’s Disease

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-02-03

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Diseases
Medicine

Abstract EN

Several studies used automated segmentation of hippocampal subfield (ASHS) for detailed measurements of anatomic subregions of the hippocampus, especially in the field of neurodegenerative disorders.

In this study, we investigated the hippocampal subfield volume of patients with early-stage nondementia PD compared with normal healthy subjects using the ASHS method.

A total of 32 subjects were enrolled in this study (sixteen patients with drug naive nondementia PD and sixteen healthy controls).

All subjects were scanned with a 1.5 tesla MRI.

The volumes of the seven subfields were calculated separately, and then, the whole hippocampal volume was calculated by the summing of CA1, CA2-3, CA4-DG, subiculum, presubiculum, and fimbria, excluding the hippocampal fissure.

There were significant diagnosis-by-hemisphere interactive effects on the total hippocampal volume (F = 5.197; p=0.031) and the subfield volume of CA2-3 (F = 7.586; p=0.010) and CA4-DG (F = 7.403; p=0.011).

The volumes of CA2-3 (F = 19.911; p<0.001), CA4-DG (F = 20.273; p<0.001), and total hippocampus (F = 10.573; p=0.005) in the left hemisphere were reduced compared to the right hemisphere.

We suggest that the hippocampal volume asymmetry, especially in CA4-DG and CA2-3, could be observed in drug-naïve PD patients even in the early stage of the disease.

American Psychological Association (APA)

Park, Jin-Woo& Lee, Chan-Nyoung& Sim, Youngbo& Ham, Hyung-Kyu& Tae, Woo-Suk& Kim, Byung-Jo. 2019. Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson’s Disease. Parkinson’s Disease،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1207024

Modern Language Association (MLA)

Park, Jin-Woo…[et al.]. Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson’s Disease. Parkinson’s Disease No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1207024

American Medical Association (AMA)

Park, Jin-Woo& Lee, Chan-Nyoung& Sim, Youngbo& Ham, Hyung-Kyu& Tae, Woo-Suk& Kim, Byung-Jo. Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson’s Disease. Parkinson’s Disease. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1207024

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1207024