7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents
Joint Authors
Nie, Shuke
Chen, Guiqin
Ma, Kai
Zhang, Zhentao
Cao, Xuebing
Sun, Mingkuan
Lee, Matthew
Tan, Yang
Zhang, Zhaohui
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
7,8-Dihydroxyflavone (7,8-DHF) is thought to be a promising therapeutic agent for various neurodegenerative diseases.
The major purpose of this study was to investigate the neuroprotective effects of 7,8-DHF on the rotenone-induced motor deficit of Parkinson’s disease.
Nine-month-old rats were treated with rotenone (2 mg/kg/day, i.h.) for 5 weeks to establish the animal model of Parkinson’s disease (PD), and 7,8-DHF (5 mg/kg, i.p.) was administrated daily throughout the whole period of rotenone injection.
Five weeks later, an open field test was used to assess the motor ability of the animals.
TH immunostaining was performed to evaluate rotenone-induced neurotoxicity on substantia nigra (SN) dopaminergic neurons and the DA terminals in the striatum.
Western blot analyses were used to examine the expressions of TH, BDNF/TrkB signaling cascades, phospho-α-synuclein (Ser129), α-synuclein, and phospho-tau (Ser396) in SN.
The results revealed that treatment with 7,8-DHF improved PD model’s behavioral performance and reduced dopaminergic neuron loss in the SN and striatum, associated with the activation of TrkB receptors and its signaling cascades, and reduced p-MAPK, p-α-synuclein, and p-tau.
Collectively, these results indicated that 7,8-DHF displayed prominent neuroprotective properties, providing a promising therapeutic strategy for PD treatment.
American Psychological Association (APA)
Nie, Shuke& Ma, Kai& Sun, Mingkuan& Lee, Matthew& Tan, Yang& Chen, Guiqin…[et al.]. 2019. 7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents. Parkinson’s Disease،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1207037
Modern Language Association (MLA)
Nie, Shuke…[et al.]. 7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents. Parkinson’s Disease No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1207037
American Medical Association (AMA)
Nie, Shuke& Ma, Kai& Sun, Mingkuan& Lee, Matthew& Tan, Yang& Chen, Guiqin…[et al.]. 7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents. Parkinson’s Disease. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1207037
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207037