Piperine Alleviates Doxorubicin-Induced Cardiotoxicity via Activating PPAR-γ in Mice
Joint Authors
Tang, Qi-Zhu
Xu, Si-Chi
Bian, Zhou-Yan
Kong, Chun-Yan
Yan, Jie
Zhou, Xiao-Yang
Yan, Ling
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Oxidative stress, inflammation and cardiac apoptosis were closely involved in doxorubicin (DOX)-induced cardiac injury.
Piperine has been reported to suppress inflammatory response and pyroptosis in macrophages.
However, whether piperine could protect the mice against DOX-related cardiac injury remain unclear.
This study aimed to investigate whether piperine inhibited DOX-related cardiac injury in mice.
Methods.
To induce DOX-related acute cardiac injury, mice in DOX group were intraperitoneally injected with a single dose of DOX (15 mg/kg).
To investigate the protective effects of piperine, mice were orally treated for 3 weeks with piperine (50 mg/kg, 18:00 every day) beginning two weeks before DOX injection.
Results.
Piperine treatment significantly alleviated DOX-induced cardiac injury, and improved cardiac function.
Piperine also reduced myocardial oxidative stress, inflammation and apoptosis in mice with DOX injection.
Piperine also improved cell viability, and reduced oxidative damage and inflammatory factors in cardiomyocytes.
We also found that piperine activated peroxisome proliferator-activated receptor-γ (PPAR-γ), and the protective effects of piperine were abolished by the treatment of the PPAR-γ antagonist in vivo and in vitro.
Conclusions.
Piperine could suppress DOX-related cardiac injury via activation of PPAR-γ in mice.
American Psychological Association (APA)
Yan, Jie& Xu, Si-Chi& Kong, Chun-Yan& Zhou, Xiao-Yang& Bian, Zhou-Yan& Yan, Ling…[et al.]. 2019. Piperine Alleviates Doxorubicin-Induced Cardiotoxicity via Activating PPAR-γ in Mice. PPAR Research،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1207111
Modern Language Association (MLA)
Yan, Jie…[et al.]. Piperine Alleviates Doxorubicin-Induced Cardiotoxicity via Activating PPAR-γ in Mice. PPAR Research No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1207111
American Medical Association (AMA)
Yan, Jie& Xu, Si-Chi& Kong, Chun-Yan& Zhou, Xiao-Yang& Bian, Zhou-Yan& Yan, Ling…[et al.]. Piperine Alleviates Doxorubicin-Induced Cardiotoxicity via Activating PPAR-γ in Mice. PPAR Research. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1207111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207111