Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR-γ Functional Module of Autophagy in Rheumatoid Arthritis
Joint Authors
Wang, Weiyan
Li, Chunling
Zhang, Zhiyi
Zhang, Yue
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Dysregulated autophagy leads to autoimmune diseases including rheumatoid arthritis (RA).
Arsenic trioxide (ATO) is a single agent used for the treatment of acute promyelocytic leukemia and is highly promising for other malignancies but is also attractive for RA, although its relationship with autophagy remains to be further clarified and its application optimized.
For the first time, we report a defective functional module of autophagy comprising the Vitamin D receptor (VDR), PPAR-γ, microtubule-associated protein 1 light-chain 3 (LC3), and p62 which appears in RA synovial fibroblasts.
ATO alleviated RA symptoms by boosting effective autophagic flux through significantly downregulating p62, the inflammation and catabolism protein.
Importantly, low-dose ATO synergizes with Vitamin D in RA treatment.
American Psychological Association (APA)
Wang, Weiyan& Li, Chunling& Zhang, Zhiyi& Zhang, Yue. 2019. Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR-γ Functional Module of Autophagy in Rheumatoid Arthritis. PPAR Research،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1207141
Modern Language Association (MLA)
Wang, Weiyan…[et al.]. Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR-γ Functional Module of Autophagy in Rheumatoid Arthritis. PPAR Research No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1207141
American Medical Association (AMA)
Wang, Weiyan& Li, Chunling& Zhang, Zhiyi& Zhang, Yue. Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR-γ Functional Module of Autophagy in Rheumatoid Arthritis. PPAR Research. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1207141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207141