Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma
Joint Authors
Morinishi, Tatsuya
Tokuhara, Yasunori
Ohsaki, Hiroyuki
Ibuki, Emi
Kadota, Kyuichi
Hirakawa, Eiichiro
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptor alpha (PPAR-α) belongs to the PPAR family and plays a critical role in inhibiting cell proliferation and tumorigenesis in various tumors.
However, the role of PPAR-α in colorectal tumorigenesis is unclear.
In the present study, we found that fenofibrate, a PPAR-α agonist, significantly inhibited cell proliferation and induced apoptosis in colorectal carcinoma cells.
In addition, PPAR-α was expressed in the nucleus of colorectal carcinoma cells, and the expression of nuclear PPAR-α increased in colorectal carcinoma tissue compared with that of normal epithelium tissue (P<0.01).
The correlation between the expression of nuclear PPAR-α and clinicopathological factors was evaluated in human colorectal carcinoma tissues, and the nuclear expression of PPAR-α was significantly higher in well-to-moderately differentiated adenocarcinoma than in mucinous adenocarcinoma (P<0.05).
These findings indicate that activation of PPAR-α may be involved in anticancer effects in colorectal carcinomas, and nuclear expression of PPAR-α may be a therapeutic target for colorectal adenocarcinoma treatment.
American Psychological Association (APA)
Morinishi, Tatsuya& Tokuhara, Yasunori& Ohsaki, Hiroyuki& Ibuki, Emi& Kadota, Kyuichi& Hirakawa, Eiichiro. 2019. Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma. PPAR Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1207146
Modern Language Association (MLA)
Morinishi, Tatsuya…[et al.]. Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma. PPAR Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1207146
American Medical Association (AMA)
Morinishi, Tatsuya& Tokuhara, Yasunori& Ohsaki, Hiroyuki& Ibuki, Emi& Kadota, Kyuichi& Hirakawa, Eiichiro. Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma. PPAR Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1207146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207146