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Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats
Joint Authors
Mao, Yu
Liu, Xuesheng
Zhang, Zhi
Gu, Erwei
Zhou, Jing
Tao, Wenjuan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Histone deacetylase inhibitors (HDACIs), which interfere with the epigenetic process of histone acetylation, have shown analgesic effects in animal models of persistent pain.
The HDAC family comprises 18 genes; however, the different effects of distinct classes of HDACIs on pain relief remain unclear.
The aim of this study was to determine the efficacy of these HDACIs on attenuating thermal hyperalgesia in persistent inflammatory pain.
Persistent inflammatory pain was induced by injecting Complete Freund’s Adjuvant (CFA) into the left hind paw of rats.
Then, HDACIs targeting class I (entinostat (MS-275)) and class IIa (sodium butyrate, valproic acid (VPA), and 4-phenylbutyric acid (4-PBA)), or class II (suberoylanilide hydoxamic acid (SAHA), trichostatin A (TSA), and dacinostat (LAQ824)) were administered intraperitoneally once daily for 3 or 4 days.
We found that the injection of SAHA once a day for 3 days significantly attenuated CFA-induced thermal hyperalgesia from day 4 and lasted 7 days.
In comparison with SAHA, suppression of hyperalgesia by 4-PBA peaked on day 2, whereas that by MS-275 occurred on days 5 and 6.
Fatigue was a serious side effect seen with MS-275.
These findings will be beneficial for optimizing the selection of specific HDACIs in medical fields such as pain medicine and neuropsychiatry.
American Psychological Association (APA)
Mao, Yu& Zhou, Jing& Liu, Xuesheng& Gu, Erwei& Zhang, Zhi& Tao, Wenjuan. 2019. Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats. Pain Research and Management،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1207208
Modern Language Association (MLA)
Mao, Yu…[et al.]. Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats. Pain Research and Management No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1207208
American Medical Association (AMA)
Mao, Yu& Zhou, Jing& Liu, Xuesheng& Gu, Erwei& Zhang, Zhi& Tao, Wenjuan. Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats. Pain Research and Management. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1207208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207208