Immunohistochemical Analysis of CD99 and PAX8 in a Series of 15 Molecularly Confirmed Cases of Ewing Sarcoma
Joint Authors
Sayagués, José María
Chinchilla-Tábora, LM.
Ortiz Rodríguez-Parets, J.
González Morais, I.
Ludeña de la Cruz, M. D.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Ewing sarcomas are an uncommon group of malignant neoplasms.
A multidisciplinary approach is highly recommended to reach a correct diagnosis, considering the clinical, radiological, and histopathological aspects.
Since in up to 90% of cases, the translocation t (11; 22) (q24; q12) occurs resulting in a chimeric fusion transcript EWSR1-FLI-1.
The pathologist has several tools in addition to conventional techniques (hematoxylin and eosin), such as immunohistochemistry, which plays a very important role in the differential diagnosis.
We present a series of 15 cases of molecularly confirmed ES, in which we found a sensitivity of 100% for CD99 and 80% for PAX8 by immunohistochemistry.
This indicates a high sensitivity; however, it is known that both CD99 and PAX8 are also expressed in other tumours.
Therefore, molecular confirmation should be performed in all cases.
American Psychological Association (APA)
Chinchilla-Tábora, LM.& Ortiz Rodríguez-Parets, J.& González Morais, I.& Sayagués, José María& Ludeña de la Cruz, M. D.. 2020. Immunohistochemical Analysis of CD99 and PAX8 in a Series of 15 Molecularly Confirmed Cases of Ewing Sarcoma. Complexity،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1207304
Modern Language Association (MLA)
Chinchilla-Tábora, LM.…[et al.]. Immunohistochemical Analysis of CD99 and PAX8 in a Series of 15 Molecularly Confirmed Cases of Ewing Sarcoma. Complexity No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1207304
American Medical Association (AMA)
Chinchilla-Tábora, LM.& Ortiz Rodríguez-Parets, J.& González Morais, I.& Sayagués, José María& Ludeña de la Cruz, M. D.. Immunohistochemical Analysis of CD99 and PAX8 in a Series of 15 Molecularly Confirmed Cases of Ewing Sarcoma. Complexity. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1207304
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207304
