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Comparison of the Effect of Tanacethum Parthenium, 5-Hydroxy Tryptophan, and Magnesium (Aurastop) versus Magnesium Alone on Aura Phenomenon and Its Evolution
Joint Authors
Volta, Giorgio Dalla
Zavarise, Paola
Perego, Laura
Savi, Lidia
Pezzini, Alessandro
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-09
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
None of the clinical trials on migraine conducted thus far have focused on the possibility to modulate the phenomenon of aura.
Furthermore, whether proper management of aura results in a better control of the headache phase has been poorly investigated.
In the setting of a single-center, pilot, clinical trial, we aimed at comparing the effects of Aurastop (a combination of tanacetum parthenium (150 mg extracted at 0.8% = 1.2 mg di of active parthenolide), griffonia simplicifoila (20 mg of 5-hydroxy tryptophan), and magnesium (185 mg of magnesium pidolatum)) with those of magnesium alone (2.25 grams/tablet, corresponding to 184 mg of Mg++) in the treatment of acute attacks of migraine with aura.
Between June 2017 and June 2018, 50 consecutive patients (27/23 male/female; mean age, 31 [18–57] years) with at least 3 episodes of aura per year were included (t0).
Participants were instructed to keep track of the following 4 episodes of migraine with aura (t1) and invited to assume (1) a tablet of Aurastop at the beginning of the following 2 episodes of aura and (2) a magnesium tablet alone at the occurrence of the third and fourth aura attacks.
Forty-eight patients (96.0%) had >50% reduction in aura duration when treated with Aurastop vs.
7 patients (14.0%) when treated with magnesium alone (p<0.001); 48 patients (96.0%) had >50% reduction of aura-related disability when receiving Aurastop vs.
5 patients (10.0%) when treated with magnesium alone (p<0.001); however, patients receiving Aurastop did not need to take pain killers in 35% of aura attacks vs.
3% when assuming magnesium (p<0.001).
These results support the hypothesis that Aurastop might be effective in interfering with the phenomenon of aura and provide evidence that the clinical benefit attributable to this combination of molecules might be greater than that obtained with single compounds of proven effect on the biology of migraine.
American Psychological Association (APA)
Volta, Giorgio Dalla& Zavarise, Paola& Perego, Laura& Savi, Lidia& Pezzini, Alessandro. 2019. Comparison of the Effect of Tanacethum Parthenium, 5-Hydroxy Tryptophan, and Magnesium (Aurastop) versus Magnesium Alone on Aura Phenomenon and Its Evolution. Pain Research and Management،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1207307
Modern Language Association (MLA)
Volta, Giorgio Dalla…[et al.]. Comparison of the Effect of Tanacethum Parthenium, 5-Hydroxy Tryptophan, and Magnesium (Aurastop) versus Magnesium Alone on Aura Phenomenon and Its Evolution. Pain Research and Management No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1207307
American Medical Association (AMA)
Volta, Giorgio Dalla& Zavarise, Paola& Perego, Laura& Savi, Lidia& Pezzini, Alessandro. Comparison of the Effect of Tanacethum Parthenium, 5-Hydroxy Tryptophan, and Magnesium (Aurastop) versus Magnesium Alone on Aura Phenomenon and Its Evolution. Pain Research and Management. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1207307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207307