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Efficacy of Platelet-Rich Plasma Containing Xenogenic Adipose Tissue-Derived Stromal Cells on Restoring Intervertebral Disc Degeneration: A Preclinical Study in a Rabbit Model
Joint Authors
Ma, Chao
Wang, Ran
Zhao, Dingliang
Wang, Naikun
Han, Ying
Wang, Shichong
Gao, Tianyun
Wang, Bin
Lu, Lijuan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Platelet-rich plasma (PRP) containing multiple growth factors is a promising strategy for disc degeneration.
Thus, this study hypothesizes that the combination of PRP and adipose tissue-derived stromal cells (ADSCs) may repair degenerative disc more effectively than using each one of them alone.
Methods.
The model of early intervertebral disc degeneration was induced by annular puncture in the New Zealand rabbit.
Autologous PRP was extracted from fresh arterial blood by using two centrifugation techniques.
ADSC was offered by the Center for Clinic Stem Cell Research.
Four weeks after the first experiment, PRP or ADSCs or a combination of PRP and ADSCs was injected into the punctured intervertebral disc.
Four weeks later, disc height and signal intensity on T2-weighted magnetic resonance imaging (MRI) were assessed.
Results.
One month after puncture, we detected relatively narrow discs and lower signal intensity in MRI T2-weighted images.
At four weeks after injection, the PRP-ADSC group statistically significantly restored discs, compared with PRP, ADSCs, or negative control group.
Conclusions.
The combination of PRP and ADSCs shows an effective potential to restore degenerated intervertebral discs in the rabbit.
American Psychological Association (APA)
Ma, Chao& Wang, Ran& Zhao, Dingliang& Wang, Naikun& Han, Ying& Wang, Shichong…[et al.]. 2019. Efficacy of Platelet-Rich Plasma Containing Xenogenic Adipose Tissue-Derived Stromal Cells on Restoring Intervertebral Disc Degeneration: A Preclinical Study in a Rabbit Model. Pain Research and Management،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1207309
Modern Language Association (MLA)
Ma, Chao…[et al.]. Efficacy of Platelet-Rich Plasma Containing Xenogenic Adipose Tissue-Derived Stromal Cells on Restoring Intervertebral Disc Degeneration: A Preclinical Study in a Rabbit Model. Pain Research and Management No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1207309
American Medical Association (AMA)
Ma, Chao& Wang, Ran& Zhao, Dingliang& Wang, Naikun& Han, Ying& Wang, Shichong…[et al.]. Efficacy of Platelet-Rich Plasma Containing Xenogenic Adipose Tissue-Derived Stromal Cells on Restoring Intervertebral Disc Degeneration: A Preclinical Study in a Rabbit Model. Pain Research and Management. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1207309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207309