Oncological Treatment Considerations Differ across Surgical Subspecialties Treating Malignant Peripheral Nerve Sheath Tumors: An International Survey
Joint Authors
Martin, Enrico
Slooff, Willem-Bart M.
van Houdt, Winan J.
van Dalen, Thijs
Coert, J. Henk
Verhoef, Kees
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Malignant peripheral nerve sheath tumors (MPNSTs) are rare and aggressive soft tissue sarcomas (STS) that, because of their origin, are operated by several surgical subspecialties.
This may cause differences in oncologic treatment recommendations based on presentation.
This study investigated these differences both within and between subspecialties.
Methods.
A survey was distributed among several (inter)national surgical societies.
Differences within and between subspecialties were analyzed by χ2-tests.
Results.
In total, 30 surgical oncologists, 30 neurosurgeons, 85 plastic surgeons, and 29 “others” filled out the survey.
Annual caseload, tumor sites operated, and fellowship training differed significantly between subspecialties.
While most surgeons agreed upon preoperative use of MRI, the use of radiological staging and FDG-PET use differed between subspecialties.
Surgical oncologists agreed upon core needle biopsies as an ideal type of biopsy while other subspecialties differed in opinion.
On average, 53% of surgeons always consider preservation of function preoperatively, but 42% would never perform less extensive resections for function preservation.
Respondents agreed that radiotherapy should be considered in tumor sizes >10 cm, microscopic, and macroscopic positive margins.
A preferred sequence of radiotherapy administration differed between subspecialties.
There was no consensus on indications and sequence of administration of chemotherapy in localized disease.
Conclusion.
Surgical oncologists generally agree on preoperative diagnostics; other subspecialties do not.
Considering the preservation of function differed among all subspecialties.
Surgeons do agree on some indications for radiotherapy, yet the use of chemotherapy in localized MPNSTs lacks consensus.
A preferred sequence of multimodal therapy differs between and within surgical subspecialties, but surgical oncologists prefer neoadjuvant radiotherapy.
American Psychological Association (APA)
Martin, Enrico& Slooff, Willem-Bart M.& van Houdt, Winan J.& van Dalen, Thijs& Verhoef, Kees& Coert, J. Henk. 2020. Oncological Treatment Considerations Differ across Surgical Subspecialties Treating Malignant Peripheral Nerve Sheath Tumors: An International Survey. Complexity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1207335
Modern Language Association (MLA)
Martin, Enrico…[et al.]. Oncological Treatment Considerations Differ across Surgical Subspecialties Treating Malignant Peripheral Nerve Sheath Tumors: An International Survey. Complexity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1207335
American Medical Association (AMA)
Martin, Enrico& Slooff, Willem-Bart M.& van Houdt, Winan J.& van Dalen, Thijs& Verhoef, Kees& Coert, J. Henk. Oncological Treatment Considerations Differ across Surgical Subspecialties Treating Malignant Peripheral Nerve Sheath Tumors: An International Survey. Complexity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1207335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207335