![](/images/graphics-bg.png)
Current Approaches for Personalized Therapy of Soft Tissue Sarcomas
Joint Authors
Kirsanov, Kirill I.
Lesovaya, Ekaterina A.
Fetisov, Timur I.
Bokhyan, Beniamin Yu
Belitsky, Gennady A.
Yakubovskaya, Marianna G.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-01
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Soft tissue sarcomas (STS) are a highly heterogeneous group of cancers of mesenchymal origin with diverse morphologies and clinical behaviors.
While surgical resection is the standard treatment for primary STS, advanced and metastatic STS patients are not eligible for surgery.
Systemic treatments, including standard chemotherapy and newer chemical agents, still play the most relevant role in the management of the disease.
Discovery of specific genetic alterations in distinct STS subtypes allowed better understanding of mechanisms driving their pathogenesis and treatment optimization.
This review focuses on the available targeted drugs or drug combinations based on genetic aberration involved in STS development including chromosomal translocations, oncogenic mutations, gene amplifications, and their perspectives in STS treatment.
Furthermore, in this review, we discuss the possible use of chemotherapy sensitivity and resistance assays (CSRA) for the adjustment of treatment for individual patients.
In summary, current trends in personalized management of advanced and metastatic STS are based on combination of both genetic testing and CSRA.
American Psychological Association (APA)
Kirsanov, Kirill I.& Lesovaya, Ekaterina A.& Fetisov, Timur I.& Bokhyan, Beniamin Yu& Belitsky, Gennady A.& Yakubovskaya, Marianna G.. 2020. Current Approaches for Personalized Therapy of Soft Tissue Sarcomas. Complexity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1207340
Modern Language Association (MLA)
Kirsanov, Kirill I.…[et al.]. Current Approaches for Personalized Therapy of Soft Tissue Sarcomas. Complexity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1207340
American Medical Association (AMA)
Kirsanov, Kirill I.& Lesovaya, Ekaterina A.& Fetisov, Timur I.& Bokhyan, Beniamin Yu& Belitsky, Gennady A.& Yakubovskaya, Marianna G.. Current Approaches for Personalized Therapy of Soft Tissue Sarcomas. Complexity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1207340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207340