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Induction of Myogenic Differentiation Improves Chemosensitivity of Chemoresistant Cells in Soft-Tissue Sarcoma Cell Lines
Joint Authors
Dawson, Lucy E.
D’Agostino, Luca
Hakim, Abraham A.
Brown, Spencer A.
Sensenig, Richard B.
Antonello, Zeus A.
Kuzin, Igor I.
Lackman, Richard
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Rhabdomyosarcoma (RMS) and rhabdoid tumors (RT) are rare soft-tissue malignancies with the highest incidence in infants, children, and adolescents.
Advanced, recurrent, and/or metastatic RMS and RT exhibit poor response to treatment.
One of the main mechanisms behind resistance to treatment is believed to be intratumoral heterogeneity.
In this study, we investigated the myogenic determination factor 1 (MYOD1) and Noggin (NOG) markers in an embryonal RMS (ERMS) cell line and an RT cell line and the differential response of the MYOD1 and NOG expressing subpopulations to chemotherapy.
Importantly, we found that these markers together identify a subpopulation of cells (MYOD1+ NOG+ cells) with primary resistance to Vincristine and Doxorubicin, two commonly used chemotherapies for ERMS and RT.
The chemoresistant MYOD1+ NOG+ cells express markers of undifferentiated cells such as myogenin and ID1.
Combination of Vincristine with TPA/GSK126, a drug combination shown to induce differentiation of RMS cell lines, is able to partially overcome MYOD1/NOG cells chemoresistance.
American Psychological Association (APA)
Dawson, Lucy E.& D’Agostino, Luca& Hakim, Abraham A.& Lackman, Richard& Brown, Spencer A.& Sensenig, Richard B.…[et al.]. 2020. Induction of Myogenic Differentiation Improves Chemosensitivity of Chemoresistant Cells in Soft-Tissue Sarcoma Cell Lines. Complexity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1207363
Modern Language Association (MLA)
Dawson, Lucy E.…[et al.]. Induction of Myogenic Differentiation Improves Chemosensitivity of Chemoresistant Cells in Soft-Tissue Sarcoma Cell Lines. Complexity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1207363
American Medical Association (AMA)
Dawson, Lucy E.& D’Agostino, Luca& Hakim, Abraham A.& Lackman, Richard& Brown, Spencer A.& Sensenig, Richard B.…[et al.]. Induction of Myogenic Differentiation Improves Chemosensitivity of Chemoresistant Cells in Soft-Tissue Sarcoma Cell Lines. Complexity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1207363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207363