Potential Association between Kaposi Sarcoma and Gout: An Exploratory Observational Study

Joint Authors

Goldstein, Daniel A.
Goldvaser, Hadar
Peretz, Idit
Zer, Alona
Moore, Assaf
Yosef, Lilach
Horn, Suzanna
Edel, Yonatan

Source

Complexity

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-01

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Philosophy

Abstract EN

Background.

Kaposi sarcoma is a rare vascular mesenchymal neoplasm, associated with Human Herpes Virus 8 (HHV8).

Gout is a condition clinically characterized by recurrent flares of arthritis and hyperuricemia.

Following our clinical impression that patients with classical Kaposi sarcoma (CKS) have a high rate of gout, we explored this in a retrospective manner.

Methods.

All consecutive patients diagnosed with sarcoma or carcinosarcoma within a single tertiary center between 1/2012–12/2017 were identified through the pathology department database.

A cohort of CKS patients was compared with the non-Kaposi sarcoma and carcinosarcoma cohort.

Data were extracted from patients’ electronic medical records.

Patients younger than 18 and patients without clinical data available were excluded.

Association between diagnosis of gout and CKS was assessed and adjusted for risk factors.

Results.

Three hundred and sixty-one patients were eligible for this analysis, 61 were diagnosed with CKS and 300 with other types of sarcoma.

We found a higher incidence of gout in CKS patients, 11/61 (18%) patients, compared with 8/300 (2.6%) with other types of sarcoma, odds ratio (OR) 8.0 (P<0.00001).

This association persisted when adjusted for age >39 years (OR = 6.7, P<0.00001), age and male sex (OR = 4.97, P<0.0001), and when adjusting for multiple confounding factors and medical comorbidities.

Conclusions.

We have demonstrated a statistically significant association between gout and CKS.

As risk factors for gout were accounted for, this association may be explained by HHV8 immune-related effects.

This should be further explored in vitro and in population-based studies.

American Psychological Association (APA)

Moore, Assaf& Peretz, Idit& Yosef, Lilach& Goldstein, Daniel A.& Goldvaser, Hadar& Horn, Suzanna…[et al.]. 2020. Potential Association between Kaposi Sarcoma and Gout: An Exploratory Observational Study. Complexity،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1207368

Modern Language Association (MLA)

Moore, Assaf…[et al.]. Potential Association between Kaposi Sarcoma and Gout: An Exploratory Observational Study. Complexity No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1207368

American Medical Association (AMA)

Moore, Assaf& Peretz, Idit& Yosef, Lilach& Goldstein, Daniel A.& Goldvaser, Hadar& Horn, Suzanna…[et al.]. Potential Association between Kaposi Sarcoma and Gout: An Exploratory Observational Study. Complexity. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1207368

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1207368