The Emerging Perspective of Morphine Tolerance: MicroRNAs
Joint Authors
Zhang, Teng J.
Qiu, Yong
Hua, Zhen
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Morphine has unfavorable side effects including analgesic tolerance.
Morphine tolerance counteracts analgesic efficacy and drives dose escalation.
The mechanisms underlying morphine tolerance remain disputed, which has prevented the development of therapies to maximize and sustain analgesic efficacy.
Morphine tolerance is an adaptive process induced by chronic morphine that has been shown to result from complex alterations at the molecular level with μ opioid receptors (MORs), as well as at the synaptic, cellular, and circuit levels.
MicroRNAs are noncoding RNAs that have been proposed to regulate gene expression and degradation at the posttranscriptional level, including the MOR, as well as synaptic plasticity and neuroplasticity, in both the peripheral and central nervous systems.
This review covers some of the most striking microRNA functions involved in morphine tolerance and presents limitations on our knowledge of their physiological roles.
American Psychological Association (APA)
Zhang, Teng J.& Qiu, Yong& Hua, Zhen. 2019. The Emerging Perspective of Morphine Tolerance: MicroRNAs. Pain Research and Management،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1207427
Modern Language Association (MLA)
Zhang, Teng J.…[et al.]. The Emerging Perspective of Morphine Tolerance: MicroRNAs. Pain Research and Management No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1207427
American Medical Association (AMA)
Zhang, Teng J.& Qiu, Yong& Hua, Zhen. The Emerging Perspective of Morphine Tolerance: MicroRNAs. Pain Research and Management. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1207427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207427