Label-Free Identification of Early Stages of Breast Ductal Carcinoma via Multiphoton Microscopy
Joint Authors
Zheng, L. Q.
Chen, Zhong
Guo, Wenhui
Kang, Deyong
Wang, Shu
Xi, Gangqin
Lian, Yuane
Wang, Chuan
Chen, Jianxin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Information Technology and Computer Science
Abstract EN
Breast cancer can be cured by early diagnosis.
Appropriate and effective clinical treatment benefits from accurate pathological diagnosis.
However, due to the lack of effective screening and diagnostic imaging methods, early stages of breast cancer often progress to malignant breast cancer.
In this study, multiphoton microscopy (MPM) via two-photon excited fluorescence combined with second-harmonic generation was used for identifying the early stages of breast ductal carcinoma.
The results showed differences in both cytological features and collagen distribution among normal breast tissue, atypical ductal hyperplasia, low-grade ductal carcinoma in situ, and high-grade ductal carcinoma in situ with microinvasion.
Furthermore, three features extracted from the MPM images were used to describe differences in cytological features, collagen density, and basement membrane circumference in the early stages of breast ductal carcinoma.
They revealed that MPM has the ability to identify early stages of breast ductal carcinoma label-free, which would contribute to the early diagnosis and treatment of breast cancer.
This study may provide the groundwork for the further application of MPM in the clinic.
American Psychological Association (APA)
Chen, Zhong& Guo, Wenhui& Kang, Deyong& Wang, Shu& Zheng, L. Q.& Xi, Gangqin…[et al.]. 2020. Label-Free Identification of Early Stages of Breast Ductal Carcinoma via Multiphoton Microscopy. Scanning،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1207531
Modern Language Association (MLA)
Chen, Zhong…[et al.]. Label-Free Identification of Early Stages of Breast Ductal Carcinoma via Multiphoton Microscopy. Scanning No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1207531
American Medical Association (AMA)
Chen, Zhong& Guo, Wenhui& Kang, Deyong& Wang, Shu& Zheng, L. Q.& Xi, Gangqin…[et al.]. Label-Free Identification of Early Stages of Breast Ductal Carcinoma via Multiphoton Microscopy. Scanning. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1207531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207531