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Two Thalamic Regions Screened Using Laser Capture Microdissection with Whole Human Genome Microarray in Schizophrenia Postmortem Samples
Joint Authors
Bakshi, Kalindi
Kemether, Eileen M.
Source
Schizophrenia Research and Treatment
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We used whole human genome microarray screening of highly enriched neuronal populations from two thalamic regions in postmortem samples from subjects with schizophrenia and controls to identify brain region-specific gene expression changes and possible transcriptional targets.
The thalamic anterior nucleus is reciprocally connected to anterior cingulate, a schizophrenia-affected cortical region, and is also thought to be schizophrenia affected; the other thalamic region is not.
Using two regions in the same subject to identify disease-relevant gene expression differences was novel and reduced intersubject heterogeneity of findings.
We found gene expression differences related to miRNA-137 and other SZ-associated microRNAs, ELAVL1, BDNF, DISC-1, MECP2 and YWHAG associated findings, synapses, and receptors.
Manual curation of our data may support transcription repression.
American Psychological Association (APA)
Bakshi, Kalindi& Kemether, Eileen M.. 2020. Two Thalamic Regions Screened Using Laser Capture Microdissection with Whole Human Genome Microarray in Schizophrenia Postmortem Samples. Schizophrenia Research and Treatment،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1207539
Modern Language Association (MLA)
Bakshi, Kalindi& Kemether, Eileen M.. Two Thalamic Regions Screened Using Laser Capture Microdissection with Whole Human Genome Microarray in Schizophrenia Postmortem Samples. Schizophrenia Research and Treatment No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1207539
American Medical Association (AMA)
Bakshi, Kalindi& Kemether, Eileen M.. Two Thalamic Regions Screened Using Laser Capture Microdissection with Whole Human Genome Microarray in Schizophrenia Postmortem Samples. Schizophrenia Research and Treatment. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1207539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207539