The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice
Joint Authors
Cardona, Diana M.
Chen, Mark
Xu, Eric S.
Leisenring, Nathan H.
Luo, Lixia
Ma, Yan
Ventura, Andrea
Kirsch, David G.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Myxoid liposarcoma is a malignant soft tissue sarcoma characterized by a pathognomonic t(12;16)(q13;p11) translocation that produces a fusion oncoprotein, FUS-CHOP.
This cancer is remarkably sensitive to radiotherapy and exhibits a unique pattern of extrapulmonary metastasis.
Here, we report the generation and characterization of a spatially and temporally restricted mouse model of sarcoma driven by FUS-CHOP.
Using different Cre drivers in the adipocyte lineage, we initiated in vivo tumorigenesis by expressing FUS-CHOP in Prrx1+ mesenchymal progenitor cells.
In contrast, expression of FUS-CHOP in more differentiated cells does not form tumors in vivo, and early expression of the oncoprotein during embryogenesis is lethal.
We also employ in vivo electroporation and CRISPR technology to rapidly generate spatially and temporally restricted mouse models of high-grade FUS-CHOP-driven sarcomas for preclinical studies.
American Psychological Association (APA)
Chen, Mark& Xu, Eric S.& Leisenring, Nathan H.& Cardona, Diana M.& Luo, Lixia& Ma, Yan…[et al.]. 2019. The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice. Complexity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1207607
Modern Language Association (MLA)
Chen, Mark…[et al.]. The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice. Complexity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1207607
American Medical Association (AMA)
Chen, Mark& Xu, Eric S.& Leisenring, Nathan H.& Cardona, Diana M.& Luo, Lixia& Ma, Yan…[et al.]. The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice. Complexity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1207607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207607